Quality criteria for in vitro human pluripotent stem cell-derived models of tissue-based cells
| العنوان: | Quality criteria for in vitro human pluripotent stem cell-derived models of tissue-based cells |
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| المؤلفون: | Francesca Pistollato, Anna Bal-Price, Sandra Coecke, Surat Parvatam, David Pamies, Katherine Czysz, Jie Hao, Kehkooi Kee, Adrian Kee Keong Teo, Shuaishuai Niu, Anja Wilmes, Lena Smirnova, Christian Freund, Christine Mummery, Glyn Stacey |
| المساهمون: | Molecular and Computational Toxicology, AIMMS |
| المصدر: | Pistollato, F, Bal-Price, A, Coecke, S, Parvatam, S, Pamies, D, Czysz, K, Hao, J, Kee, K, Teo, A K K, Niu, S, Wilmes, A, Smirnova, L, Freund, C, Mummery, C & Stacey, G 2022, ' Quality criteria for in vitro human pluripotent stem cell-derived models of tissue-based cells ', Reproductive Toxicology, vol. 112, pp. 36-50 . https://doi.org/10.1016/j.reprotox.2022.06.003 Reproductive Toxicology, 112, 36-50. Elsevier Inc. Reproductive Toxicology, 112, 36-50. PERGAMON-ELSEVIER SCIENCE LTD |
| بيانات النشر: | Elsevier BV, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pluripotent Stem Cells, GCCP, Invitrotoxicology, Induced Pluripotent Stem Cells, Endoderm, Cell Culture Techniques, Reproducibility of Results, Humanpluripotentstemcells, iPSCs, Cell Differentiation, Quality control criteria, Readiness level, Toxicology, Mesoderm, SDG 3 - Good Health and Well-being, Differentiation, Ectoderm, Humans, Human pluripotent stem cells, Qualitycontrolcriteria, Readinesslevel, 3D, In vitro toxicology |
| الوصف: | The advent of the technology to isolate or generate human pluripotent stem cells provided the potential to develop a wide range of human models that could enhance understanding of mechanisms underlying human development and disease. These systems are now beginning to mature and provide the basis for the development of in vitro assays suitable to understand the biological processes involved in the multi-organ systems of the human body, and will improve strategies for diagnosis, prevention, therapies and precision medicine. Induced pluripotent stem cell lines are prone to phenotypic and genotypic changes and donor/clone dependent variability, which means that it is important to identify the most appropriate characterization markers and quality control measures when sourcing new cell lines and assessing differentiated cell and tissue culture preparations for experimental work. This paper considers those core quality control measures for human pluripotent stem cell lines and evaluates the state of play in the development of key functional markers for their differentiated cell derivatives to promote assurance of reproducibility of scientific data derived from pluripotent stem cell-based systems. |
| وصف الملف: | application/pdf |
| تدمد: | 0890-6238 |
| DOI: | 10.1016/j.reprotox.2022.06.003 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8146a56e62179eec18f54a0202bf68df https://doi.org/10.1016/j.reprotox.2022.06.003 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8146a56e62179eec18f54a0202bf68df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08906238 |
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| DOI: | 10.1016/j.reprotox.2022.06.003 |