Association between up-titration of medical therapy and total hospitalizations and mortality in patients with recent worsening heart failure across the ejection fraction spectrum
| العنوان: | Association between up-titration of medical therapy and total hospitalizations and mortality in patients with recent worsening heart failure across the ejection fraction spectrum |
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| المؤلفون: | Faiez Zannad, John Parissis, Gerasimos Filippatos, Marco Metra, Eftihia Polyzogopoulou, Adriaan A. Voors, Stefan D. Anker, Dirk J. van Veldhuisen, Kalliopi Keramida, John G.F. Cleland, Dimitrios Farmakis, Vasiliki Bistola, Panagiotis Simitsis, Nilesh J. Samani, Wouter Ouwerkerk |
| المساهمون: | National and Kapodistrian University of Athens (NKUA), Attikon University Hospital, National Heart Centre Singapore (NHCS), Amsterdam UMC - Amsterdam University Medical Center, University Medical Center Groningen [Groningen] (UMCG), National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, University of Glasgow, Charité Campus Virchow-Klinikum (CVK), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Berlin-Brandenburg Center for Regenerative Medicine [Berlin, Germany] (BCRT), University of Leicester, Glenfield Hospital, University of Brescia, Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia [Brescia], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), This project was funded by a grant from the European Commission (FP7-242209-BIOSTAT-CHF, EudraCT 2010-020808-29)., European Project: 242209,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,BIOSTAT-CHF(2010), European Project, BOZEC, Erwan, A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure - BIOSTAT-CHF - - EC:FP7:HEALTH2010-04-01 - 2015-03-31 - 242209 - VALID, EudraCT 2010–020808–29 - INCOMING, Cardiovascular Centre (CVC), Epidemiology and Data Science |
| المصدر: | European Journal of Heart Failure European Journal of Heart Failure, 2021, 23 (7), pp.1170-1181. ⟨10.1002/ejhf.2219⟩ European Journal of Heart Failure, 23(7). Wiley European journal of heart failure, 23(7), 1170-1181. Wiley-Blackwell |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, MODELS, Left, Worsening heart failure, 030204 cardiovascular system & hematology, Ventricular Function, Left, EVENTS, Renin–angiotensin system inhibitors, MORBIDITY, 03 medical and health sciences, Beta-blockers, Angiotensin Receptor Antagonists, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine, Humans, Ventricular Function, In patient, Hospitalizations, Mortality, Renin-angiotensin system inhibitors, Hospitalization, Stroke Volume, Heart Failure, Ejection fraction, RECURRENT HOSPITALIZATIONS, business.industry, Hazard ratio, medicine.disease, Confidence interval, TIME, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Heart failure, Cardiology, Shared frailty, Cardiology and Cardiovascular Medicine, business, Lower mortality, Medical therapy |
| الوصف: | Background: \ud The role of neurohormonal inhibition in chronic heart failure is well established. There is limited data on the effect of up-titration of renin angiotensin inhibition (RASi) and beta-blockers (BBs) on clinical outcomes of patients with worsening heart failure (HF) across the left ventricular ejection fraction (LVEF) spectrum.\ud \ud Methods and results: \ud We analyzed data from 2345 patients from BIOSTAT-CHF (80.9% LVEF |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1388-9842 |
| DOI: | 10.1002/ejhf.2219⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813734a5ecbc1f9eecce96d8d0335761 http://hdl.handle.net/11379/558558 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....813734a5ecbc1f9eecce96d8d0335761 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13889842 |
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| DOI: | 10.1002/ejhf.2219⟩ |