Visualizing artery‐specific blood flow patterns above the circle of Willis with vessel‐encoded arterial spin labeling
| العنوان: | Visualizing artery‐specific blood flow patterns above the circle of Willis with vessel‐encoded arterial spin labeling |
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| المؤلفون: | Peter Jezzard, Thomas W. Okell, Meritxell Garcia, Michael A. Chappell, James V. Byrne |
| المصدر: | Magnetic Resonance in Medicine |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | vascular territory imaging, Adult, Male, Full Papers—Imaging Methodology, Dynamic angiography, arteriovenous malformation, Signal-To-Noise Ratio, vessel‐encoded pseudocontinuous arterial spin labeling (VEPCASL), 030218 nuclear medicine & medical imaging, Arteriovenous Malformations, 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, medicine.artery, Image Processing, Computer-Assisted, medicine, Humans, Radiology, Nuclear Medicine and imaging, Full Paper, medicine.diagnostic_test, business.industry, Angiography, Hemodynamics, Brain, Arteriovenous malformation, Arteries, Blood flow, Middle Aged, Image Enhancement, medicine.disease, vessel‐selective, Healthy Volunteers, dynamic angiography, Perfusion, medicine.anatomical_structure, Cerebrovascular Circulation, Arterial spin labeling, Circle of Willis, Female, Spin Labels, business, Nuclear medicine, Blood Flow Velocity, 030217 neurology & neurosurgery, Artery |
| الوصف: | Purpose: To establish the feasibility of using vessel-encoded pseudocontinuous arterial spin labeling (VEPCASL) for non-invasive vascular territory imaging (VTI) and artery-specific dynamic angiography of a large number of arterial branches above the circle of Willis within a clinically feasible scan time. Methods: 3D time-of-flight angiography was used to select a labeling plane and establish seven pairs of encoding cycles. These were used for VEPCASL VTI and dynamic 2D angiography (8 min and 3 min acquisition times, respectively) in healthy volunteers, allowing the separation of signals arising from 13 arterial branches (including extracranial arteries) in post-processing. To demonstrate the clinical potential of this approach, VEPCASL angiography was also applied in five patients with brain arteriovenous malformation (AVM). Results: In healthy volunteers, the artery-specific filling of the vascular tree and resulting perfusion territories were well depicted. Signal-to-noise ratios were approximately five times higher than those achievable with single-artery selective methods. Blood supply to the AVMs was well visualized in all cases, showing the main feeding arteries and venous drainage. Conclusions: VEPCASL is a highly efficient method for both VTI and dynamic angiography of a large number of arterial branches, providing a comprehensive picture of vascular flow patterns and the effect on downstream tissue perfusion within an acceptable scan time. Automation of labeling plane and vessel-encoding selection would improve robustness and efficiency, and further refinement could allow quantitative blood flow measurements to be obtained. This technique shows promise for visualizing the blood supply to lesions and collateral flow patterns. |
| تدمد: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.27507 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811caee861e877c8067e55e9c6f61f43 https://doi.org/10.1002/mrm.27507 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....811caee861e877c8067e55e9c6f61f43 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15222594 07403194 |
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| DOI: | 10.1002/mrm.27507 |