التفاصيل البيبلوغرافية
| العنوان: |
Adipose Tissue Fibrosis: Mechanisms, Models, and Importance |
| المؤلفون: |
Rosalyn D. Abbott, Megan K. DeBari |
| المصدر: |
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6030, p 6030 (2020) |
| بيانات النشر: |
Carnegie Mellon University, 2020. |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
0301 basic medicine, Pathology, Adipose tissue, Biocompatible Materials, Review, lcsh:Chemistry, Tissue Culture Techniques, Extracellular matrix, chemistry.chemical_compound, 0302 clinical medicine, Weight loss, Fibrosis, Adipocyte, Adipocytes, lcsh:QH301-705.5, Spectroscopy, in vitro models, General Medicine, Extracellular Matrix, Computer Science Applications, adipose tissue, 030220 oncology & carcinogenesis, in vivo models, medicine.symptom, biomaterials, medicine.medical_specialty, Rodentia, Inflammation, Catalysis, Inorganic Chemistry, 03 medical and health sciences, In vivo, medicine, Genetics, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, business.industry, Organic Chemistry, fibrosis, Insulin sensitivity, medicine.disease, Epidemiologic Studies, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, chemistry, FOS: Biological sciences, business |
| الوصف: |
Increases in adipocyte volume and tissue mass due to obesity can result in inflammation, further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like other fibrotic diseases, adipose tissue fibrosis is the accumulation and increased production of extracellular matrix (ECM) proteins. Adipose tissue fibrosis has been linked to decreased insulin sensitivity, poor bariatric surgery outcomes, and difficulty in weight loss. With the rising rates of obesity, it is important to create accurate models for adipose tissue fibrosis to gain mechanistic insights and develop targeted treatments. This article discusses recent research in modeling adipose tissue fibrosis using in vivo and in vitro (2D and 3D) methods with considerations for biomaterial selections. Additionally, this article outlines the importance of adipose tissue in treating other fibrotic diseases and methods used to detect and characterize adipose tissue fibrosis. |
| DOI: |
10.1184/r1/13286645 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8103a00f2edd46ed218837e33f40f73b |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....8103a00f2edd46ed218837e33f40f73b |
| قاعدة البيانات: |
OpenAIRE |