Depth-profile of impairments in endothelin-1 – induced focal cortical ischemia
| العنوان: | Depth-profile of impairments in endothelin-1 – induced focal cortical ischemia |
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| المؤلفون: | Daria Vinokurova, Andrey Zakharov, Kseniya Chernova, Gulshat Burkhanova-Zakirova, Viktor Horst, Coline L Lemale, Jens P Dreier, Roustem Khazipov |
| المساهمون: | Kazan Federal University (KFU), Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] (INMED - INSERM U1249), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Kazan State University (KPFU), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Bernstein Center for Computational Neuroscience [Berlin], Humboldt University Of Berlin |
| المصدر: | Journal of Cerebral Blood Flow and Metabolism Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2022, pp.0271678X2211074. ⟨10.1177/0271678X221107422⟩ J Cereb Blood Flow Metab |
| بيانات النشر: | SAGE Publications, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Endothelin-1, Neurology, Ischemia, Cortical Spreading Depression, Animals, Humans, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Original Articles, Neurology (clinical), Iridium, Cardiology and Cardiovascular Medicine, Brain Ischemia, Rats |
| الوصف: | International audience; The development of ischemic lesions has primarily been studied in horizontal cortical space. However, how ischemic lesions develop through the cortical depth remains largely unknown. We explored this question using direct current coupled recordings at different cortical depths using linear arrays of iridium electrodes in the focal epipial endothelin-1 (ET1) ischemia model in the rat barrel cortex. ET1-induced impairments were characterized by a vertical gradient with (i) rapid suppression of the spontaneous activity in the superficial cortical layers at the onset of ischemia, (ii) compartmentalization of spreading depolarizations (SDs) to the deep layers during progression of ischemia, and (iii) deeper suppression of activity and larger histological lesion size in superficial cortical layers. The level of impairments correlated strongly with the rate of spontaneous activity suppression, the rate of SD onset after ET1 application, and the amplitude of giant negative ultraslow potentials (∼−70 mV), which developed during ET1 application and were similar to the tent-shaped ultraslow potentials observed during focal ischemia in the human cortex. Thus, in the epipial ET1 ischemia model, ischemic lesions develop progressively from the surface to the cortical depth, and early changes in electrical activity at the onset of ET1-induced ischemia reliably predict the severity of ischemic damage. |
| تدمد: | 1559-7016 0271-678X |
| DOI: | 10.1177/0271678x221107422 |
| DOI: | 10.1177/0271678X221107422⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cde7ad9742fd0d980e92ce5cb436c1 https://doi.org/10.1177/0271678x221107422 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....80cde7ad9742fd0d980e92ce5cb436c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15597016 0271678X |
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| DOI: | 10.1177/0271678x221107422 |