IgG1 anti-cell wall and IgG2 anti-phosphopeptidomannan antibodies in the diagnosis of invasive candidiasis and heavy Candida colonization
| العنوان: | IgG1 anti-cell wall and IgG2 anti-phosphopeptidomannan antibodies in the diagnosis of invasive candidiasis and heavy Candida colonization |
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| المؤلفون: | Inger Mattsby-Baltzer, Nahid Kondori, Hervé Pelloux, Leila Potton, Claudine Pinel, Javier Yugueros Marcos, Muriel Cornet, Anne Thiebaut-Bertrand |
| المساهمون: | Department of Infectious Medicine/Clinical Bacteriology, University of Gothenburg (GU), IRCELYON-C'Durable (CDURABLE), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] (LAPM), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), TheREx, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF) |
| المصدر: | Medical Mycology Medical Mycology, Oxford University Press, 2015, 53 (7), pp.725-735. ⟨10.1093/mmy/myv037⟩ |
| بيانات النشر: | HAL CCSD, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Phosphopeptides, medicine.medical_specialty, Antigens, Fungal, Arbitrary unit, Neutropenia, Sensitivity and Specificity, Gastroenterology, Immunoglobulin G, Microbiology, Mannans, Young Adult, Cell Wall, Internal medicine, Humans, Medicine, Candidiasis, Invasive, Candida albicans, Antibodies, Fungal, ComputingMilieux_MISCELLANEOUS, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, Aged, Candida, Retrospective Studies, Aged, 80 and over, biology, Receiver operating characteristic, business.industry, General Medicine, Invasive candidiasis, Middle Aged, medicine.disease, biology.organism_classification, Confidence interval, 3. Good health, Infectious Diseases, ROC Curve, biology.protein, Female, Antibody, business |
| الوصف: | We conducted a retrospective study to evaluate the usefulness of immunoglobulin G (IgG) subclasses against Candida cell wall fragments (CW) and phosphopeptidomannan (PPM) for the diagnosis of invasive candidiasis (IC). We analyzed 54 patients with IC (n = 19), Candida heavy colonization (HC; n = 16), and controls (no IC or HC, n = 19).In nonneutropenic patients (n = 47), the sensitivity and specificity values of IgG1 anti-CW and IgG2 anti-PPM in IC were 88%, 59%, and 88%, 94%, respectively. The areas under the receiver operating characteristic curves were 0.69 (0.51-0.88) and 0.901 (0.78-1.02), respectively. IgG1 mean values (arbitrary units) and 95% confidence interval were 46 (20-71), 42 (-0.38 to 84) and 20 (8.3-32) in IC, HC, and in controls, respectively, and discriminated IC but not HC from controls (P = .032, and P = .77, respectively). IgG2 mean values were 26 (9.2-42), 19 (4.4-33), and 3.2 (0.28-6.6) in IC, HC, and in controls, respectively, and discriminated both IC and HC from controls (P < .0001 and P = .035, respectively) but did not separate IC from HC (P = .2). IgG2 showed positivity as early as one day after the IC diagnosis. Antibodies were detected in only two out of a total of seven neutropenic patients.For both IC and HC patients, the diagnostic performance of IgG2 anti-PPM was better than the one of IgG1 anti-CW. In nonneutropenic patients, IgG2 anti-PPM accurately identified not only IC patients but also HC patients at high risk for IC. This marker may help clinicians in the initiation of early preemptive therapy. |
| اللغة: | English |
| تدمد: | 1369-3786 1365-280X |
| DOI: | 10.1093/mmy/myv037⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8041ca1f3a101d8bb73b66ba85ec759a https://hal.archives-ouvertes.fr/hal-01470819 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8041ca1f3a101d8bb73b66ba85ec759a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13693786 1365280X |
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| DOI: | 10.1093/mmy/myv037⟩ |