Calculation of beta dosimetry in radiation synovectomy using Monte Carlo simulation (EGS4)

التفاصيل البيبلوغرافية
العنوان: Calculation of beta dosimetry in radiation synovectomy using Monte Carlo simulation (EGS4)
المؤلفون: L. Scott Johnson, Jacquelyn C. Yanch
المصدر: Medical Physics. 20:747-754
بيانات النشر: Wiley, 1993.
سنة النشر: 1993
مصطلحات موضوعية: musculoskeletal diseases, Materials science, medicine.medical_treatment, Monte Carlo method, Synovectomy, Arthritis, Rheumatoid, Joint capsule, Beta particle, Dysprosium, medicine, Humans, Dosimetry, Computer Simulation, Yttrium Radioisotopes, Irradiation, Radiometry, Radioisotopes, Gold Radioisotopes, business.industry, Synovial Membrane, General Medicine, Beta Particles, Radiation therapy, medicine.anatomical_structure, Absorbed dose, Nuclear medicine, business, Monte Carlo Method, Phosphorus Radioisotopes
الوصف: Using the EGS4 Monte Carlo code, absorbed dose rate factors were estimated for four radionuclides of interest in radiation synovectomy, an intra-articular radiation therapy to treat rheumatoid arthritis. The treatment consists of the injection of a beta-emitting radionuclide into the joint capsule in order to eliminate diseased synovium through irradiation. The radionuclides investigated are 32P, 90Y, 165Dy, and 198Au. Calculations reveal the absorbed dose factor (cGy cm2/MBq s) as a function of distance (mm) in an EGS4 model of the rheumatic joint. The model incorporates bone, articular cartilage, joint capsule, and tissue (synovium) components found in all synovial joints, with dimensions in the model corresponding to dimensions typically found in larger joints, e.g., the knee, shoulder, or hip. Results are compared with previous, analytical approaches to beta dosimetry in radiation synovectomy. In addition, radiation backscatter due to the presence of bone is investigated and determined to have a negligible enhancement effect on absorbed dose to synovium.
تدمد: 0094-2405
DOI: 10.1118/1.597028
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8023f3b176d53fc0177a3aa841a82202
https://doi.org/10.1118/1.597028
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....8023f3b176d53fc0177a3aa841a82202
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00942405
DOI:10.1118/1.597028