Use of X-ray scattering to aid the design and delivery of membrane-active drugs
| العنوان: | Use of X-ray scattering to aid the design and delivery of membrane-active drugs |
|---|---|
| المؤلفون: | Georg Pabst, Ruth Prassl, Dagmar Zweytick, Karl Lohner |
| المصدر: | European Biophysics Journal. 41:915-929 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Liposome, Chemistry, Membrane lipids, Cell Membrane, Lipid Bilayers, Biophysics, Membrane biology, Membrane Proteins, Biological membrane, General Medicine, Membrane, X-Ray Diffraction, Biochemistry, Drug Design, Liposomes, Drug delivery, Animals, Humans, Sphingomyelin, Lipid bilayer |
| الوصف: | Biological membranes can be targets for compounds that either disrupt their barrier function or affect protein function via membrane-mediated processes. Biophysical studies on membrane-mimetic systems composed of membrane lipids have contributed substantially to our knowledge on the pertaining membrane physics and aid the development of membrane-specific drugs. Moreover, lipid membranes and, in particular, liposomes are convenient systems for drug delivery. We review some of our recent work that demonstrates the applicability of X-ray scattering to understanding the molecular mechanisms of drug-membrane interactions. In particular we focus on effects of anesthetics, sphingomyelinase, and antimicrobial peptides. We further discuss X-ray scattering as a quality-control tool for liposomal drug-delivery systems. |
| تدمد: | 1432-1017 0175-7571 |
| DOI: | 10.1007/s00249-012-0821-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7a9940b15552e6f2b6d687fad8b92e https://doi.org/10.1007/s00249-012-0821-9 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7f7a9940b15552e6f2b6d687fad8b92e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321017 01757571 |
|---|---|
| DOI: | 10.1007/s00249-012-0821-9 |