Alterations in Spinal Cord Metabolism during Treatment of Neuropathic Pain
| العنوان: | Alterations in Spinal Cord Metabolism during Treatment of Neuropathic Pain |
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| المؤلفون: | Caroline H. Johnson, Gary Siuzdak, Leah P. Shriver, Marianne Manchester, Linh Hoang, Gary J. Patti, Jean-Philippe Courade |
| المصدر: | Journal of Neuroimmune Pharmacology. 10:396-401 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, medicine.drug_class, Metabolite, Immunology, Central nervous system, Pregabalin, Neuroscience (miscellaneous), Oleic Acids, Endogeny, Pharmacology, Antimetabolite, Article, Rats, Sprague-Dawley, chemistry.chemical_compound, Sphingosine, medicine, Animals, Metabolomics, Immunology and Allergy, Cannabinoid Receptor Agonists, Analgesics, business.industry, Lipid metabolism, Spinal cord, Rats, Disease Models, Animal, medicine.anatomical_structure, Spinal Cord, chemistry, Ethanolamines, Neuropathic pain, Neuralgia, business, Endocannabinoids, medicine.drug |
| الوصف: | Therapeutic options for neuropathic pain have improved over the last 20 years yet still only provide partial relief with numerous side effects. Recently, metabolomics revealed that the concentration of the endogenous metabolite N,N-dimethylsphingosine (DMS) is increased in the spinal cord in a model of neuropathic pain. Additionally, it was shown that introduction of DMS to the central nervous system (CNS) resulted in mechanical allodynia. Here, we have examined two compounds; pregabalin (Lyrica®), a drug used to treat neuropathic pain, and N-oleoylethanolamine (NOE), an endogenous endocannabinoid-like compound that is known to affect multiple lipid pathways. We found that the concentration of DMS in the spinal cord was not significantly altered upon pregabalin treatment of rats suffering from neuropathic pain. We further explored whether modulating lipid metabolism may impact neuropathic pain by testing NOE as a potential novel therapeutic. |
| تدمد: | 1557-1904 1557-1890 |
| DOI: | 10.1007/s11481-015-9624-y |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f708a7e6516c95edba4129273da1af7 https://doi.org/10.1007/s11481-015-9624-y |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7f708a7e6516c95edba4129273da1af7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15571904 15571890 |
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| DOI: | 10.1007/s11481-015-9624-y |