Microscopic intraosseous extension of osteosarcoma: assessment on dynamic contrast-enhanced MRI
| العنوان: | Microscopic intraosseous extension of osteosarcoma: assessment on dynamic contrast-enhanced MRI |
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| المؤلفون: | Hirokazu Nishihira, T. Iwasawa, Gen Nishimura, Shigeharu Okuzumi, Yukichi Tanaka, Noriko Aida |
| المصدر: | Skeletal Radiology. 26:214-221 |
| بيانات النشر: | Springer Science and Business Media LLC, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Male, Adolescent, medicine.medical_treatment, Contrast Media, Bone Neoplasms, Resection, Humans, Medicine, Neoplasm Invasiveness, Radiology, Nuclear Medicine and imaging, In patient, Child, Retrospective Studies, Histological examination, Osteosarcoma, Chemotherapy, business.industry, Humerus, medicine.disease, Magnetic Resonance Imaging, Chemotherapy, Adjuvant, Dynamic contrast-enhanced MRI, Female, Signal intensity, business, Nuclear medicine, Complication |
| الوصف: | Objective. This study investigated whether dynamic MRI could determine microscopic intraosseous invasion in osteosarcoma. Patients. Six patients with osteosarcoma who underwent total resection of the tumor after chemotherapy were studied. Design. The steepest slope value of the time-intensity curve was calculated on the basis of the first-pass method on dynamic MRI performed after chemotherapy. Slope value modified log=[100·(SIb−SIa)/(Tb−Ta)/SIa], where SIa and SIb represent the signal intensity at time points Ta and Tb when the steepest slope started and ended, respectively. The slope value was correlated with the histological findings of the surgical specimens. The findings on conventional MRI were also reviewed. Results and conclusions. In five of six patients microscopic tumor invasion ranging from 1 to 3.5 cm in depth was pathologically proven. The slope value within the microscopic invasion (−0.052±0.267) was significantly greater than that of tumour-free marrow (−0.609±0.220) and less than that in areas showing macroscopic tumor invasion (0.595±0.483) (P |
| تدمد: | 1432-2161 0364-2348 |
| DOI: | 10.1007/s002560050224 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f23537e60093fa4655987d23b5e1866 https://doi.org/10.1007/s002560050224 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7f23537e60093fa4655987d23b5e1866 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322161 03642348 |
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| DOI: | 10.1007/s002560050224 |