أعرض في EDS

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

التفاصيل البيبلوغرافية
العنوان: Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
المؤلفون: Benjamin Voight, Amelie Bonnefond, Mark Caulfield, Jong-Young Lee, Ruth Loos, Nancy Heard-Costa, Eleftheria Zeggini, Cristiano FAVA, Anna Gloyn, Michael Preuss, Åsa Johansson, LAURA CRISPONI, Eco De Geus, Michael Weedon, Jeanne Clark, Francesco CUCCA, Marjo-Riitta Jarvelin, Torben Jørgensen, Andrea Maschio, Kirsi Pietiläinen, Nicole Glazer, Jaakko Kaprio, Valur Emilsson, Goncalo Abecasis, Andrew Taylor, Nicole Soranzo, Serena Sanna, Patricia Munroe, Ozren Polasek, Jan A. Staessen, Jennie Hui, Elina Hypponen, ROBERTO ELOSUA, Yurii Aulchenko, Michael Stumvoll, Andrew Hattersley, Bruce H.R. Wolffenbuttel, Alexander Doney, Peter P Pramstaller, Christian Dina, Lambertus Kiemeney, Sophie Visvikis-Siest, Mohammad Arfan Ikram, ANGELO SCUTERI, Udo Seedorf, Behrooz Ziad Alizadeh, John Whitfield, Vilmundur Gudnason, Maris Laan, Chris Wallace, Gavin Lucas, E Shyong Tai, Peter Kraft, Michael Marmot, Thor Aspelund, Dale Nyholt, Christian Gieger, Mika Kivimaki, Michael Sternberg, Lorena Citterio, Weiguo Zhang, Mary Feitosa, María Soler Artigas, Claudia Langenberg, Mika Ala-Korpela, Stavroula Kanoni, Uwe Völker, Mika Kähönen, Tomonori Okamura, Marcus Dörr, David Hillman, Lachlan Coin, Gideon Hirschfield, Eric Brunner, Maryam Kavousi, Terho Lehtimäki, Man Li, Carsten Oliver Schmidt, John Beilby, Peter Visscher, Sally Ricketts, Katja Aben, Halit Ongen, Christie Ballantyne, Adebowale Adeyemo, Fabio Marroni, Willem Ouwehand, Toby Johnson, Meena Kumari, Peter Kovacs, Debbie A Lawlor, Jianjun Liu, Grant Montgomery, Nicholas Martin, Francesco Mattace-Raso, Inga Prokopenko, Rafn Benediktsson, Margus Viigimaa, Peter Würtz, Philippe Froguel, Fadi Charchar, Soumya Raychaudhuri, Wolfram Goessling, Alena Yaluri, Cornelia Van Duijn, Timothy Frayling, Daniel Shriner, Nita Forouhi, Jana Van Vliet-Ostaptchouk, Bram Prins, Peter Whincup, David MASSON, Ronald Stolk, Ayse Demirkan, Janoš Terzić, James Pirruccello, Maciej Tomaszewski, Martin Tobin, Ko Willems van Dijk, John Carr, Elin Org, Reedik Mägi, Xiaofeng Zhu, Gerard Waeber, Koichi Matsuda, Winston Hide, Lyle John Palmer, Francois Pattou, Dorairaj Prabhakaran, Markus M. Lerch, Mark Wass, Claes Ohlsson, Paul O'Reilly, Vasiliki Lagou, Pedro Marques-Vidal, Sudha Seshadri, Tom Gaunt, Peter Wurz, Giriraj Ratan Chandak, Louise Wain, Antti Kangas, Matthijs Boekholdt, Niels Grarup, Jemma Hopewell, Thomas Meitinger, Lina Zgaga, Dag Steinar Thelle, Robert Weyant, Thomas Wang, Paul Elliott, Robert Luben, Albert Vernon Smith, Vinod Kumar, Pankaj Arora, MANUELA UDA, Daniel Gudbjartsson, Avan Aihie Sayer, Christa Meisinger, Kirsten Ohm Kyvik, Ming-Huei Chen, Susana Eyheramendy, Kenechi Ejebe, Stephen E Humphries, Ioanna Tzoulaki, Florian Kronenberg, Richard Bergman, Laura Zagato, Carlo Rivolta, NILUFER RAHMIOGLU, Vasan Ramachandran, Anna Dominiczak, Gonneke Willemsen, Mark McCarthy, Cecilia Lindgren, Olle Melander, Igor Rudan, Xueling Sim, Hugh Watkins, Edward Lakatta
المساهمون: Other departments, Experimental Vascular Medicine, Vascular Medicine, ACS - Amsterdam Cardiovascular Sciences, Cardiology, Biological Psychology, Neuroscience Campus Amsterdam - Anxiety & Depression, Neuroscience Campus Amsterdam - Attention & Cognition, EMGO+ - Mental Health, Chambers, John C, Zhang, Weihua, Sehmi, Joban, Li, Xiunzhong, Hypponen, Elina, Kooner, Jaspal S, Cardiovascular Centre (CVC), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Faculteit Medische Wetenschappen/UMCG, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM), Psychiatry, NCA - Anxiety & Depression, NCA - Attention & Cognition, EMGO - Mental health, Epidemiology, Surgery, Gastroenterology & Hepatology, Pediatrics, Internal Medicine, Ehret, Georg Benedikt
المصدر: Nature Genetics, 43, 11, pp. 1131-8
Nature genetics
Nature genetics, 43(11), 1131-U129. Nature Publishing Group
Nature Genetics, 43, 1131-8
Nature Genetics, 43(11), 1131-1140. Nature Publishing Group
Kyvik, K O 2011, ' Genome-wide association study identifies loci influencing concentration of liver enzymes in plasma ', Nature Genetics, vol. 43, no. 11, pp. 1131-38 . https://doi.org/10.1038/ng.970
Chambers, J C, Zhang, W, Sehmi, J, Li, X, Wass, M N, Van der Harst, P, Holm, H, Sanna, S, Kavousi, M, Baumeister, S E, Coin, L J, Deng, G, Gieger, C, Heard-Costa, N L, Hottenga, J-J, Kühnel, B, Kumar, V, Lagou, V, Liang, L, Luan, J, Vidal, P M, Mateo Leach, I, O'Reilly, P F, Peden, J F, Rahmioglu, N, Soininen, P, Speliotes, E K, Yuan, X, Thorleifsson, G, Alizadeh, B Z, Atwood, L D, Borecki, I B, Brown, M J, Charoen, P, Cucca, F, Das, D, de Geus, E J C, Dixon, A L, Döring, A, Ehret, G, Eyjolfsson, G I, Farrall, M, Forouhi, N G, Friedrich, N, Goessling, W, Gudbjartsson, D F, Harris, T B, Hartikainen, A-L, Heath, S & Hayward, C 2011, ' Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma ', Nature Genetics, vol. 43, no. 11, pp. 1131-8 . https://doi.org/10.1038/ng.970
Nature Genetics, 43(11), 1131-U129. Nature Publishing Group
Nature Genetics
Nature Genetics, 43(11), 1131-U129
Chambers, J C, Zhang, W, Sehmi, J, Li, X, Wass, M N, van der Harst, P, Holm, H, Sanna, S, Kavousi, M, Baumeister, S E, Hottenga, J J, Speliotes, E K, de Geus, E J C, Martin, N G, Montgomery, G W, Penninx, B W J H, Prokopenko, I, Spector, T D, Uitterlinden, A G, Willemsen, G, Abecasis, G R, Boomsma, D I, van Duijn, C M, Snieder, H, Whitfield, J B, Witteman, J C M, Fox, C S, Ala-Korpela, M, Stefansson, K, Vollenweider, P, Völzke, H, Schadt, E E, Scott, J, Jarvelin, M R, Elliot, P & Kooner, J S 2011, ' Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma ', Nature Genetics, vol. 43, no. 11, pp. 1131-1140 . https://doi.org/10.1038/ng.970
Nature Genetics, Vol. 43, No 11 (2011) pp. 1131-8
Nature Genetics; Vol 43
سنة النشر: 2011
مصطلحات موضوعية: Netherlands Twin Register (NTR), Candidate gene, Genome-wide association study, Liver disease, Delta-5 Fatty Acid Desaturase, 0302 clinical medicine, HEPATOCELLULAR-CARCINOMA, GENETIC-VARIANTS, METABOLIC SYNDROME, ddc:616, Genetics, 0303 health sciences, Glycobiology, GWAS, liver enzymes, COMMON VARIANTS, Genomics, Single Nucleotide, C-REACTIVE PROTEIN, Enzymes, 3. Good health, GWAS liver enzymes plasma, Blood, Liver, 030220 oncology & carcinogenesis, HEREDITARY CHOLESTASIS, SUSCEPTIBILITY LOCI, Locus (genetics), Biology, Polymorphism, Single Nucleotide, Article, Enzymes/blood/genetics, Molecular epidemiology [NCEBP 1], 03 medical and health sciences, SDG 3 - Good Health and Well-being, medicine, Humans, CORONARY-HEART-DISEASE, Polymorphism, Gene, 030304 developmental biology, Hormonal regulation [IGMD 6], Liver/enzymology, Lipid metabolism, medicine.disease, SALT EXPORT PUMP, RISK-FACTORS, Genome-Wide Association Study, Liver function
الوصف: Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10(-8) to P = 10(-190)). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function. Major support for the work came from European Commission (FP5, FP6 and FP7); European Science Foundation; European Science Council
وصف الملف: application/pdf
تدمد: 1061-4036
1546-1718
DOI: 10.1038/ng.970
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edb28f9648063ec49efcad3a2ef319a
https://hdl.handle.net/2066/95932
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....7edb28f9648063ec49efcad3a2ef319a
قاعدة البيانات: OpenAIRE
الوصف
تدمد:10614036
15461718
DOI:10.1038/ng.970