Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy
| العنوان: | Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy |
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| المؤلفون: | Tadao Tanaka, Chikage Narui, Aikou Okamoto, Kazuko Matsuoka, Souta Fukushima, Naomi Harano, Keiichi Iwaya, Kenji Umayahara, Masaru Sakamoto, Yuki Koike, Shinnosuke Iwai, Shingo Horikawa, Rinko Ozeki, Kayo Suzuki |
| المصدر: | Current Oncology, Vol 28, Iss 397, Pp 4709-4720 (2021) Current Oncology Volume 28 Issue 6 Pages 397-4720 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, cervical cancer, Trachelectomy, Sentinel lymph node, Article, chemistry.chemical_compound, sentinel lymph node, Biopsy, Medicine, Humans, Fertility preservation, Stage (cooking), Lymph node, RC254-282, Neoplasm Staging, Cervical cancer, medicine.diagnostic_test, business.industry, Sentinel Lymph Node Biopsy, abdominal radical trachelectomy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, fertility sparing, body regions, photodynamic eye, medicine.anatomical_structure, chemistry, Lymphatic Metastasis, Female, Radiology, business, Indocyanine green |
| الوصف: | This study aimed to assess the accuracy of predicting pelvic lymph node status using sentinel lymph node (SLN) biopsy with indocyanine green (ICG) and to examine the outcomes of SLN biopsy-guided abdominal radical trachelectomy (ART). Patients with stage IA2–IB2 cervical cancer from January 2009 to January 2021 were included. ICG was injected before ART and SLNs were identified, excised, and assessed intraoperatively using fast-frozen sections. Systemic pelvic lymphadenectomy was subsequently performed. The SLN detection rate, sensitivity, and false-negative rate were determined. Thirty patients desiring fertility preservation were enrolled, of whom 26 successfully completed ART and four underwent radical hysterectomies because of metastatic primary SLNs. Bilateral SLNs were identified in all patients. The sensitivity, false-negative rate, and negative predictive value were 100%, 7.7%, and 92.3%, respectively. Three (12%) patients were lost to follow-up: two relapsed and one died of tumor progression. Of the nine patients who tried to conceive after surgery, four achieved pregnancy and three delivered healthy live infants. In women with early-stage cervical cancer who desired to conserve fertility, SLN mapping with ICG had a very high detection rate, sensitivity, and low false-negative rate. SLN biopsy-guided ART is a feasible and accurate method for assessing pelvic node status. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1198-0052 1718-7729 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea91aa7f3c1f5d26f1287bad245bcf0 https://www.mdpi.com/1718-7729/28/6/397 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7ea91aa7f3c1f5d26f1287bad245bcf0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11980052 17187729 |
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