Comparison of micro- and nanoscale Fe⁺³-containing (Hematite) particles for their toxicological properties in human lung cells in vitro
| العنوان: | Comparison of micro- and nanoscale Fe⁺³-containing (Hematite) particles for their toxicological properties in human lung cells in vitro |
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| المؤلفون: | Christof Schulz, Thomas A. J. Kuhlbusch, Hugh J. Byrne, Eik Hoffmann, Eva-Maria Prantl, Jens Boertz, Qamar Rahman, Elke Dopp, Hartmut Wiggers, Roel F. P. Schins, Kunal Bhattacharya, Gerrit M. Alink |
| المساهمون: | Hugh J. Byrne, PRTLI Cycle 4, INSPIRE |
| المصدر: | Toxicological sciences 126 (2012) 1 Toxicological sciences, 126(1), 173-182 Articles |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Chemical Phenomena, Medizin, Nanoparticle, Metal Nanoparticles, Toxicology, medicine.disease_cause, Ferric Compounds, chemistry.chemical_compound, Maschinenbau, Microscale chemistry, Magnetite, Cell Line, Transformed, chemistry.chemical_classification, Membrane Potential, Mitochondrial, Physics, Endocytosis, visual_art, visual_art.visual_art_medium, cytotoxicity, Comet Assay, Cell Survival, Surface Properties, Oxide, Nanotechnology, Bronchi, protein corona, Microscopy, Electron, Transmission, medicine, Humans, nanoscale particles, Particle Size, Toxicologie, VLAG, Biomolecule, genotoxicity, microscale particles, radical formation, Electron Spin Resonance Spectroscopy, toxicity, Epithelial Cells, Hematite, Fibroblasts, rats, ferric-oxide, chemistry, Chemical engineering, Solubility, Microscopy, Electron, Scanning, nanoparticles, Particle size, Reactive Oxygen Species, Genotoxicity, DNA Damage |
| الوصف: | The specific properties of nanoscale particles, large surface-to-mass ratios and highly reactive surfaces, have increased their commercial application in many fields. However, the same properties are also important for the interaction and bioaccumulation of the nonbiodegradable nanoscale particles in a biological system and are a cause for concern. Hematite (alpha-Fe2O3), being a mineral form of Fe(III) oxide, is one of the most used iron oxides besides magnetite. The aim of our study was the characterization and comparison of biophysical reactivity and toxicological effects of alpha-Fe2O3 nano- (d 50 mu g/ml). The nanoscale particles were slightly more potent in causing cyto- and genotoxicity as compared with their microscale counterparts. Both types of particles induced intracellular generation of reactive oxygen species. This study underlines that alpha-Fe2O3 nanoscale particles trigger different toxicological reaction pathways than microscale particles. However, the immediate environment of the particles (biomolecules, physiological properties of medium) modulates their toxicity on the basis of agglomeration rather than their actual size. |
| وصف الملف: | application/pdf; application/octet-stream |
| تدمد: | 1096-0929 1096-6080 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1979c070ff9e8fba3ad846f401d941 https://pubmed.ncbi.nlm.nih.gov/22262566 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7e1979c070ff9e8fba3ad846f401d941 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10960929 10966080 |
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