A Novel Method for Quantifying In-Vivo Regional Left Ventricular Myocardial Contractility in the Border Zone of a Myocardial Infarction
| العنوان: | A Novel Method for Quantifying In-Vivo Regional Left Ventricular Myocardial Contractility in the Border Zone of a Myocardial Infarction |
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| المؤلفون: | Zhihong Zhang, Lik Chuan Lee, Jonathan F. Wenk, Arthur W. Wallace, Doron Klepach, Julius M. Guccione, Liang Ge, Mark B. Ratcliffe, David Saloner |
| المصدر: | Journal of Biomechanical Engineering. 133 |
| بيانات النشر: | ASME International, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Heart Ventricles, Finite Element Analysis, Myocardial Infarction, Biomedical Engineering, Technical Brief, Blood Pressure, Contractility, Imaging, Three-Dimensional, In vivo, Physiology (medical), Internal medicine, medicine, Animals, Myocardial infarction, Physics, Sheep, medicine.diagnostic_test, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Myocardial Contraction, Left Ventricular Aneurysm, medicine.anatomical_structure, Homogeneous, Ventricle, Cardiology, Stress, Mechanical, Border zone, Biomedical engineering |
| الوصف: | Homogeneous contractility is usually assigned to the remote region, border zone (BZ), and the infarct in existing infarcted left ventricle (LV) mathematical models. Within the LV, the contractile function is therefore discontinuous. Here, we hypothesize that the BZ may in fact define a smooth linear transition in contractility between the remote region and the infarct. To test this hypothesis, we developed a mathematical model of a sheep LV having an anteroapical infarct with linearly–varying BZ contractility. Using an existing optimization method (Sun et al., 2009, “A Computationally Efficient Formal Optimization of Regional Myocardial Contractility in a Sheep With Left Ventricular Aneurysm,” J. Biomech. Eng., 131(11), pp. 111001), we use that model to extract active material parameter Tmax and BZ width dn that “best” predict in–vivo systolic strain fields measured from tagged magnetic resonance images (MRI). We confirm our hypothesis by showing that our model, compared to one that has homogeneous contractility assigned in each region, reduces the mean square errors between the predicted and the measured strain fields. Because the peak fiber stress differs significantly (∼15%) between these two models, our result suggests that future mathematical LV models, particularly those used to analyze myocardial infarction treatment, should account for a smooth linear transition in contractility within the BZ. |
| تدمد: | 1528-8951 0148-0731 |
| DOI: | 10.1115/1.4004995 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1e160062229c95f41cfc66e1a59b98 https://doi.org/10.1115/1.4004995 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7d1e160062229c95f41cfc66e1a59b98 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15288951 01480731 |
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| DOI: | 10.1115/1.4004995 |