Necrotizing fasciitis: pathogenesis and treatment
| العنوان: | Necrotizing fasciitis: pathogenesis and treatment |
|---|---|
| المؤلفون: | David M. Aronoff, Michael H Young, N. Cary Engleberg |
| المصدر: | Expert Review of Anti-infective Therapy. 3:279-294 |
| بيانات النشر: | Informa UK Limited, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Microbiology (medical), medicine.medical_specialty, Streptococcus pyogenes, Disease, Microbiology, Pathogenesis, Risk Factors, Virology, medicine, Humans, Combined Modality Therapy, Fasciitis, Necrotizing, Fasciitis, Intensive care medicine, Septic shock, business.industry, Incidence, Mortality rate, Clindamycin, medicine.disease, United States, Anti-Bacterial Agents, Infectious Diseases, Debridement, Infectious disease (medical specialty), business, medicine.drug |
| الوصف: | Necrotizing fasciitis is a rapidly progressive, life-threatening infection and a true infectious disease emergency. Despite much clinical experience, the management of this disease remains suboptimal, with mortality rates remaining approximately 30%. Necrotizing fasciitis rarely presents with obvious signs and symptoms and delays in diagnosis enhance mortality. Therefore, successful patient care depends on the physician's acumen and index of suspicion. Prompt surgical debridement, intravenous antibiotics, fluid and electrolyte management, and analgesia are mainstays of therapy. Adjunctive clindamycin, hyperbaric oxygen therapy and intravenous immunoglobulin are frequently employed in the treatment of necrotizing fasciitis, but their efficacy has not been rigorously established. Improved understanding of the pathogenesis of necrotizing fasciitis has revealed new targets for rationally designed therapies to improve morbidity and mortality. |
| تدمد: | 1744-8336 1478-7210 |
| DOI: | 10.1586/14787210.3.2.279 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d15d28414aca69674f8b7add903812c https://doi.org/10.1586/14787210.3.2.279 |
| رقم الانضمام: | edsair.doi.dedup.....7d15d28414aca69674f8b7add903812c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17448336 14787210 |
|---|---|
| DOI: | 10.1586/14787210.3.2.279 |