NTRK2 gene fusions are uncommon in pilocytic astrocytoma
| العنوان: | NTRK2 gene fusions are uncommon in pilocytic astrocytoma |
|---|---|
| المؤلفون: | Daniel Antunes Moreno, Aline Paixão Becker, Cristovam Scapulatempo-Neto, Weder Menezes, Jamie Sheren, Aline M Walter, Carlos Clara, Hélio R. Machado, Ricardo S. Oliveira, Luciano Neder, Marileila Varella-Garcia, Rui Manuel Reis |
| المصدر: | Molecular Biology Reports. 49:7567-7573 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Proto-Oncogene Proteins B-raf, Brain Neoplasms, Genetics, Humans, Glioma, General Medicine, Astrocytoma, Gene Fusion, Molecular Biology, In Situ Hybridization, Fluorescence |
| الوصف: | Pilocytic astrocytoma is the most frequent pediatric glioma. Despite its overall good prognosis, complete surgical resection is sometimes unfeasible, especially for patients with deep-seated tumors. For these patients, the identification of targetable genetic alterations such as NTRK fusions, raised as a new hope for therapy. The presence of gene fusions involving NTRK2 has been rarely reported in pilocytic astrocytoma. The aim of the present study was to investigate the frequency of NTRK2 alterations in a series of Brazilian pilocytic astrocytomas.Sixty-nine pilocytic astrocytomas, previously characterized for BRAF and FGFR1 alterations were evaluated. The analysis of NTRK2 alterations was performed using a dual color break apart fluorescence in situ hybridization (FISH) assay.NTRK2 fusions were successfully evaluated by FISH in 62 of the 69 cases. Neither evidence of NTRK2 gene rearrangements nor NTRK2 copy number alterations were found.NTRK2 alterations are uncommon genetic events in pilocytic astrocytomas, regardless of patients' clinicopathological and molecular features. |
| تدمد: | 1573-4978 0301-4851 |
| DOI: | 10.1007/s11033-022-07567-y |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce0b66eaeadbeaec86daf1f58054031 https://doi.org/10.1007/s11033-022-07567-y |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7ce0b66eaeadbeaec86daf1f58054031 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734978 03014851 |
|---|---|
| DOI: | 10.1007/s11033-022-07567-y |