التفاصيل البيبلوغرافية
العنوان:
Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity
المؤلفون:
Leonardo Luís Artico , Leandro Martínez , Andrew J. Brooks , Leticia Fröhlich Archangelo , Livia Weijenborg Campos , Gisele Olinto Libanio Rodrigues , Thais Rafael Guimarães , Priscila Pini Zenatti , Leonardo Granato Pissinato , José Andrés Yunes
المصدر:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
بيانات النشر:
American Society of Hematology, 2019.
سنة النشر:
2019
مصطلحات موضوعية:
0301 basic medicine , Carcinogenesis , Immunoglobulin gamma-Chains , Immunology , Sequence Homology , medicine.disease_cause , Biochemistry , Interleukin-7 Receptor alpha Subunit , Mice , 03 medical and health sciences , 0302 clinical medicine , Extracellular , medicine , Animals , Humans , Amino Acid Sequence , Receptors, Immunologic , Interleukin-7 receptor , Receptor , Peptide sequence , STAT5 , HIPERSENSIBILIDADE , chemistry.chemical_classification , B-Lymphocytes , Mice, Inbred C3H , Mutation , biology , Chemistry , Amino Acids, Basic , Interleukin-7 , Cell Membrane , Cell Biology , Hematology , Amino acid , Cell biology , Mutagenesis, Insertional , 030104 developmental biology , biology.protein , Phosphorylation , Female , 030215 immunology
الوصف:
TO THE EDITOR: The receptor for interleukin-7 (IL-7) is formed by the IL7RA and the IL2RG (γc) chains. IL-7 leads to the reciprocal phosphorylation of IL7RA-associated JAK1 and γc-associated JAK3, followed by phosphorylation of IL7RA and then STAT5 anchoring and activation. Constitutive signaling
تدمد:
1528-0020
DOI:
10.1182/blood-2018-09-872945
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9a187eac3117ae8d7ac94793611618 https://doi.org/10.1182/blood-2018-09-872945
Rights:
OPEN
رقم الانضمام:
edsair.doi.dedup.....7c9a187eac3117ae8d7ac94793611618
قاعدة البيانات:
OpenAIRE