Whole-brain dynamics differentiate among cisgender and transgender individuals
| العنوان: | Whole-brain dynamics differentiate among cisgender and transgender individuals |
|---|---|
| المؤلفون: | Carme Uribe, Anira Escrichs, Eleonora de Filippi, Yonatan Sanz‐Perl, Carme Junque, Esther Gomez‐Gil, Morten L. Kringelbach, Antonio Guillamon, Gustavo Deco |
| المصدر: | Dipòsit Digital de la UB Universidad de Barcelona Uribe, C, Escrichs, A, de Filippi, E, Sanz-Perl, Y, Junque, C, Gomez-Gil, E, Kringelbach, M L, Guillamon, A & Deco, G 2022, ' Whole-brain dynamics differentiate among cisgender and transgender individuals ', Human Brain Mapping, vol. 43, no. 13, pp. 4103-4115 . https://doi.org/10.1002/hbm.25905 Human Brain Mapping |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Radiological and Ultrasound Technology, Brain, Gender Identity, dynamical complexity, whole-brain dynamics, transgender, Transgender Persons, Diagnòstic per la imatge, Transgender people, Identitat sexual, Neurology, Transgèneres, Gender identity, sex/gender differences, ignition, Diagnostic imaging, Humans, Radiology, Nuclear Medicine and imaging, Female, Neurology (clinical), Anatomy, Cervell, cisgender |
| الوصف: | How the brain represents gender identity is largely unknown, but some neural differences have recently been discovered. We used an intrinsic ignition framework to investigate whether there are gender differences in the propagation of neural activity across the whole-brain and within resting-state networks. Studying 29 trans men and 17 trans women with gender incongruence, 22 cis women, and 19 cis men, we computed the capability of a given brain area in space to propagate activity to other areas (mean-ignition), and the variability across time for each brain area (node-metastability). We found that both measurements differentiated all groups across the whole brain. At the network level, we found that compared to the other groups, cis men showed higher mean-ignition of the dorsal attention network and node-metastability of the dorsal and ventral attention, executive control, and temporal parietal networks. We also found higher mean-ignition values in cis men than in cis women within the executive control network, but higher mean-ignition in cis women than cis men and trans men for the default mode. Node-metastability was higher in cis men than cis women in the somatomotor network, while both mean-ignition and node-metastability were higher for cis men than trans men in the limbic network. Finally, we computed correlations between these measurements and a body image satisfaction score. Trans men's dissatisfaction as well as cis men's and cis women's satisfaction toward their own body image were distinctively associated with specific networks in each group. Overall, the study of the whole-brain network dynamical complexity discriminates gender identity groups, functional dynamic approaches could help disentangle the complex nature of the gender dimension in the brain. H2020 Excellent Science, Grant/Award Number: 945539; H2020 Marie Skłodowska-Curie Actions, Grant/Award Number: 888692; Ministerio de Ciencia e Innovación, Grant/Award Numbers: PGC2018-094919-B-C21, PID2019-105772GB |
| وصف الملف: | application/pdf |
| تدمد: | 1097-0193 |
| DOI: | 10.1002/hbm.25905 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3d900ebd155ee069e96d6505178b11 https://pubmed.ncbi.nlm.nih.gov/35583382 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7c3d900ebd155ee069e96d6505178b11 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970193 |
|---|---|
| DOI: | 10.1002/hbm.25905 |