Intra-fraction displacement of the prostate bed during post-prostatectomy radiotherapy
| العنوان: | Intra-fraction displacement of the prostate bed during post-prostatectomy radiotherapy |
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| المؤلفون: | Andrew Kneebone, Regina Bromley, Linda J. Bell, George Hruby, Thomas Eade |
| المصدر: | Radiation Oncology (London, England) Radiation Oncology, Vol 16, Iss 1, Pp 1-11 (2021) |
| بيانات النشر: | BioMed Central, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | lcsh:Medical physics. Medical radiology. Nuclear medicine, Male, Cone beam computed tomography, Post prostatectomy radiotherapy, lcsh:R895-920, medicine.medical_treatment, Rectum, lcsh:RC254-282, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Intra-fraction motion, Prostate bed, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Displacement (orthopedic surgery), IGRT, Image-guided radiation therapy, Retrospective Studies, Prostatectomy, Radiotherapy, business.industry, Research, Post-prostatectomy, Prostate, Soft tissue, Prostatic Neoplasms, Cone-Beam Computed Tomography, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Radiation therapy, medicine.anatomical_structure, Oncology, Prostate Bed, 030220 oncology & carcinogenesis, business, Nuclear medicine, Radiotherapy, Image-Guided |
| الوصف: | Background To measure intra-fraction displacement (IFD) in post-prostatectomy patients treated with anisotropic margins and daily soft tissue matching. Methods Pre-treatment cone beam computed tomography (CBCT) scans were acquired daily and post-treatment CBCTs for the first week then weekly on 46 patients. The displacement between the scans was calculated retrospectively to measure IFD of the prostate bed (PB). The marginal miss (MM) rate, and the effect of time between imaging was assessed. Results A total of 392 post-treatment CBCT’s were reviewed from 46 patients. The absolute mean (95% CI) IFD was 1.5 mm (1.3–1.7 mm) in the AP direction, 1.0 mm (0.9–1.2 mm) SI, 0.8 mm (0.7–0.9 mm) LR, and 2.4 mm (2.2–2.5 mm) 3D displacement. IFD ≥ ± 3 mm and ≥ ± 5 mm was 24.7% and 5.4% respectively. MM of the PB was detected in 33 of 392 post-treatment CBCT (8.4%) and lymph nodes in 6 of 211 post-treatment CBCT images (2.8%). Causes of MM due to IFD included changes in the bladder (87.9%), rectum (66.7%) and buttock muscles (6%). A time ≥ 9 min between the pre and post-treatment CBCT demonstrated that movement ≥ 3 mm and 5 mm increased from 19.2 to 40.5% and 5 to 8.1% respectively. Conclusions IFD during PB irradiation was typically small, but was a major contributor to an 8.4% MM rate when using daily soft tissue match and tight anisotropic margins. |
| اللغة: | English |
| تدمد: | 1748-717X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1c4a2b2a47cc32a4ba2ff065c3754f http://europepmc.org/articles/PMC7821719 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7c1c4a2b2a47cc32a4ba2ff065c3754f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1748717X |
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