Monte Carlo simulations of receptor dynamics: Insights into cell signaling
| العنوان: | Monte Carlo simulations of receptor dynamics: Insights into cell signaling |
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| المؤلفون: | Jennifer J. Linderman, Christopher J. Brinkerhoff, Peter J. Woolf |
| المصدر: | The Histochemical Journal. 35:667-677 |
| بيانات النشر: | Springer Science and Business Media LLC, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Agonist, Cell signaling, Histology, Physiology, medicine.drug_class, Monte Carlo method, Integrin, Antagonist, Receptors, Cell Surface, Cell Biology, General Medicine, Biology, Second Messenger Systems, Cell biology, Desensitization (telecommunications), Cell Adhesion, medicine, biology.protein, Anatomy, Signal transduction, Receptor, Dimerization, Monte Carlo Method |
| الوصف: | Many receptor-level processes involve the diffusion and reaction of receptors with other membrane-localized molecules. Monte Carlo simulation is a powerful technique that allows us to track the motions and discrete reactions of individual receptors, thus simulating receptor dynamics and the early events of signal transduction. In this paper, we discuss simulations of two receptor processes, receptor dimerization and G-protein activation. Our first set of simulations demonstrates how receptor dimerization can create clusters of receptors via partner switching and the relevance of this clustering for receptor cross-talk and integrin signaling. Our second set of simulations investigates the activation and desensitization of G-protein coupled receptors when either a single agonist or both an agonist and an antagonist are present. For G-protein coupled receptor systems in the presence of an agonist alone, the dissociation rate constant of agonist is predicted to affect the ratio of G-protein activation to receptor phosphorylation. Similarly, this ratio is affected by the antagonist dissociation rate constant when both agonist and antagonist are present. The relationship of simulation predictions to experimental findings and potential applications of our findings are also discussed. |
| تدمد: | 1573-6865 1567-2379 |
| DOI: | 10.1007/s10735-004-2663-y |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b609ae138471d4e90f352deaa1307ae https://doi.org/10.1007/s10735-004-2663-y |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7b609ae138471d4e90f352deaa1307ae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15736865 15672379 |
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| DOI: | 10.1007/s10735-004-2663-y |