IFNL4 Genotype Does Not Associate with CD4 T-Cell Recovery in People Living with Human Immunodeficiency Virus
| العنوان: | IFNL4 Genotype Does Not Associate with CD4 T-Cell Recovery in People Living with Human Immunodeficiency Virus |
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| المؤلفون: | David W. Haas, Eric G. Meissner, Betty P. Tsao, Dongjun Chung, Netanya S. Utay |
| المصدر: | AIDS Res Hum Retroviruses |
| بيانات النشر: | Mary Ann Liebert Inc, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Infectious Diseases, Immune system, Cd4 t cell, business.industry, Virology, Immunology, Genotype, Human immunodeficiency virus (HIV), medicine, Spite, medicine.disease_cause, business |
| الوصف: | Immune non-responders (INRs) are people with HIV infection who fail to restore their CD4 T-cell counts in spite of prolonged virologic suppression, a condition associated with higher rates of all-cause mortality. The mechanisms of immune non-response are not entirely clear. We used existing clinical and genetic data from AIDS Clinical Trials Group clinical trials to ask whether an IFNL4 single-nucleotide polymorphism, shown to be associated with outcomes for other infectious diseases, correlated with immune non-response for HIV. Analysis of data from 426 participants with clearly defined CD4 T-cell recovery phenotypes, including 88 INRs with CD4 |
| تدمد: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2020.0104 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7c0d7c171a0a8d530fd695c8436353 https://doi.org/10.1089/aid.2020.0104 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7a7c0d7c171a0a8d530fd695c8436353 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19318405 08892229 |
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| DOI: | 10.1089/aid.2020.0104 |