Morphologic Characteristics of Chernobyl-Related Childhood Papillary Thyroid Carcinomas Are Independent of Radiation Exposure but Vary with Iodine Intake
| العنوان: | Morphologic Characteristics of Chernobyl-Related Childhood Papillary Thyroid Carcinomas Are Independent of Radiation Exposure but Vary with Iodine Intake |
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| المؤلفون: | Geraldine A. Thomas, Anatoly F. Tsyb, Evgeny P. Demidchik, Alexander Abrosimov, Virginia A. LiVolsi, Sarah L. Vowler, Juan Rosai, Masahiro Ito, E. Dillwyn Williams, Mikola D. Tronko, Tatiana Bogdanova, E Lushnikov |
| المصدر: | Thyroid. 18:847-852 |
| بيانات النشر: | Mary Ann Liebert Inc, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Neoplasms, Radiation-Induced, Republic of Belarus, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Physiology, Radiation Dosage, Chernobyl Nuclear Accident, Russia, Original Studies, Reviews and Scholarly Dialog, Thyroid carcinoma, Endocrinology, Japan, Carcinoma, medicine, Humans, Short latency, Thyroid Neoplasms, Child, Iodine intake, Wales, business.industry, Incidence (epidemiology), Infant, medicine.disease, Iodine deficiency, Carcinoma, Papillary, humanities, Diet, Radiation exposure, England, Ukraine, business, Iodine |
| الوصف: | The Chernobyl accident caused an unprecedented increase in papillary thyroid carcinoma (PTC) incidence with a surprisingly short latency and unusual morphology. We have investigated whether unexpected features of the PTC incidence after Chernobyl were radiation specific or influenced by iodine deficiency.PTCs from children from Belarus, Ukraine, and the Russian Federation exposed to fallout from Chernobyl were compared with PTCs from children not exposed to radiation from the same countries, from England and Wales (EW) and from Japan. The degree and type of differentiation, fibrosis, and invasion were quantified.There were no significant differences between PTCs from radiation-exposed children from Belarus, Ukraine, and the Russian Federation and PTCs from children from the same countries who were not exposed to radiation. Childhood PTCs from Japan were much more highly differentiated (p0.001), showed more papillary differentiation (p0.001) and were less invasive (p0.01) than "Chernobyl" tumors, while tumors from EW generally showed intermediate levels of degree and type of differentiation and invasion. There was a marked difference between the sex ratios of children with PTCs who were radiation exposed and those who were not exposed (F:M exposed vs. unexposed 1.5:1 vs. 4.2:1; chi(2) = 7.90, por = 0.01005).The aggressiveness and morphological features of Chernobyl childhood PTCs are not associated with radiation exposure. The differences found between tumors from the Chernobyl area, EW, and Japan could be influenced by many factors. We speculate that dietary iodine levels may have wide implications in radiation-induced thyroid carcinogenesis, and that iodine deficiency could increase incidence, reduce latency, and influence tumor morphology and aggressiveness. |
| تدمد: | 1557-9077 1050-7256 |
| DOI: | 10.1089/thy.2008.0039 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a62ca360905a5aaa8ec9a34d8cbe955 https://doi.org/10.1089/thy.2008.0039 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7a62ca360905a5aaa8ec9a34d8cbe955 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15579077 10507256 |
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| DOI: | 10.1089/thy.2008.0039 |