Psychoactive plant- and mushroom-associated alkaloids from two behavior modifying cicada pathogens
| العنوان: | Psychoactive plant- and mushroom-associated alkaloids from two behavior modifying cicada pathogens |
|---|---|
| المؤلفون: | Henrik H. De Fine Licht, Matthew D. Maust, Kristen L. Wickert, Chris Simon, Matthew T. Kasson, Ellie J. Spahr, Kathie T. Hodge, Greg R. Boyce, William J. Davis, Terry Gullion, Dylan P. G. Short, Teiya Kijimoto, Timothy Y. James, Gene Kritsky, Amy M. Metheny, Richard A. Humber, Jason C. Slot, Cameron M. Stauder, Nidia Arguedas, John R. Cooley, Jørgen Eilenberg, Jason E. Stajich, Angie M. Macias, Emile Gluck-Thaler, Dan Mozgai, Matthew C. Berger, Daniel G. Panaccione |
| المصدر: | Boyce, Greg; Gluck-Thaler, Emile; Slot, Jason; Stajich, Jason; Davis, William; James, Tim; et al.(2018). Psychoactive plant-and mushroom-associated alkaloids from two behavior modifying cicada pathogens. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/3wz7q482 Boyce, G R, Gluck-Thaler, E, Slot, J C, Stajich, J E, Davis, W J, James, T Y, Cooley, J R, Panaccione, D G, Eilenberg, J, De Fine Licht, H H, Macias, A M, Berger, M C, Wickert, K L, Stauder, C M, Spahr, E J, Maust, M D, Metheny, A M, Simon, C, Kritsky, G, Hodge, K T, Humber, R A, Gullion, T, Short, D P G, Kijimoto, T, Mozgai, D, Arguedas, N & Kasson, M T 2019, ' Psychoactive plant-and mushroom-associated alkaloids from two behavior modifying cicada pathogens ', Fungal Ecology, vol. 41, pp. 147-164 . https://doi.org/10.1016/j.funeco.2019.06.002 Fungal ecology |
| بيانات النشر: | Cold Spring Harbor Laboratory, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Tryptamine, 0106 biological sciences, Psilocin, Plant Science, Entomopathogen, Biology, Magicicada, 010603 evolutionary biology, 01 natural sciences, Article, Psilocybin, Microbiology, chemistry.chemical_compound, Invertebrate pathology, 03 medical and health sciences, Metabolomics, Okanagana, medicine, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Psychoactive plant, Platypedia, 0303 health sciences, Mushroom, Ecology, Host (biology), Ecological Modeling, fungi, Massospora, biology.organism_classification, 3. Good health, Spore, Entomophthorales, Amphetamine, Cathinone, chemistry, Periodical cicadas, Biological dispersal, Zoopagomycota, Massospora cicadina, 010606 plant biology & botany, medicine.drug |
| الوصف: | Entomopathogenic fungi routinely kill their hosts before releasing infectious spores, but select species keep insects alive while sporulating, which enhances dispersal. Transcriptomics and metabolomics studies of entomopathogens with post-mortem dissemination from their parasitized hosts have unraveled infection processes and host responses, yet mechanisms underlying active spore transmission by Entomophthoralean fungi in living insects remain elusive. Here we report the discovery, through metabolomics, of the plant-associated amphetamine, cathinone, in four Massospora cicadina-infected periodical cicada populations, and the mushroom-associated tryptamine, psilocybin, in annual cicadas infected with Massospora platypediae or Massospora levispora, which appear to represent a single fungal species. The absence of some fungal enzymes necessary for cathinone and psilocybin biosynthesis along with the inability to detect intermediate metabolites or gene orthologs are consistent with possibly novel biosynthesis pathways in Massospora. The neurogenic activities of these compounds suggest the extended phenotype of Massospora that modifies cicada behavior to maximize dissemination is chemically-induced. |
| وصف الملف: | application/pdf |
| DOI: | 10.1101/375105 |
| DOI: | 10.1016/j.funeco.2019.06.002 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a39b80f8e44905ee221b44ef1cbf7a0 https://doi.org/10.1101/375105 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7a39b80f8e44905ee221b44ef1cbf7a0 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.1101/375105 |
|---|