Should open excisions and sutured incisions be treated differently? A review and meta-analysis of animal wound models following low-level laser therapy
| العنوان: | Should open excisions and sutured incisions be treated differently? A review and meta-analysis of animal wound models following low-level laser therapy |
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| المؤلفون: | František Sabol, Petr Gál, Erik Dosedla, Ivan Kováč, Martin Bjørn Stausholm, Jan Magnus Bjordal, Ján Luczy |
| المصدر: | Lasers in Medical Science. 33:1351-1362 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, 030103 biophysics, medicine.medical_specialty, Red laser, medicine.medical_treatment, Surgical Wound, Dermatology, Controlled studies, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Laser therapy, Tensile Strength, Diabetes Mellitus, Animals, Medicine, Low-Level Light Therapy, Low level laser therapy, Wound Healing, Sutures, business.industry, Contraction analysis, Surgery, Disease Models, Animal, Meta-analysis, Wounds and Injuries, Sutured wounds, business, Wound healing |
| الوصف: | Although low-level laser therapy (LLLT) was discovered already in the 1960s of the twentieth century, it took almost 40 years to be widely used in clinical dermatology/surgery. It has been demonstrated that LLLT is able to increase collagen production/wound stiffness and/or improve wound contraction. In this review, we investigated whether open and sutured wounds should be treated with different LLLT parameters. A PubMed search was performed to identify controlled studies with LLLT applied to wounded animals (sutured incisions—tensile strength measurement and open excisions—area measurement). Final score random effects meta-analyses were conducted. Nineteen studies were included. The overall result of the tensile strength analysis (eight studies) was significantly in favor of LLLT (SMD = 1.06, 95% CI 0.66–1.46), and better results were seen with 30–79 mW/cm2 infrared laser (SMD = 1.44, 95% CI 0.67–2.21) and 139–281 mW/cm2 red laser (SMD = 1.52, 95% CI 0.54–2.49). The overall result of the wound contraction analysis (11 studies) was significantly in favor of LLLT (SMD = 0.99, 95% CI 0.38–1.59), and the best results were seen with 53–300 mW/cm2 infrared laser (SMD = 1.18, 95% CI 0.41–1.94) and 25–90 mW/cm2 red laser (SMD = 1.6, 95% CI 0.27–2.93). Whereas 1–15 mW/cm2 red laser had a moderately positive effect on sutured wounds, 2–4 mW/cm2 red laser did not accelerate healing of open wounds. LLLT appears effective in the treatment of sutured and open wounds. Statistical heterogeneity indicates that the tensile strength development of sutured wounds is more dependent on laser power density compared to the contraction rate of open wounds. |
| تدمد: | 1435-604X 0268-8921 |
| DOI: | 10.1007/s10103-018-2496-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a347e31c474c49f48e9d2017a0c26d8 https://doi.org/10.1007/s10103-018-2496-7 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7a347e31c474c49f48e9d2017a0c26d8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1435604X 02688921 |
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| DOI: | 10.1007/s10103-018-2496-7 |