Histopathology of Cerebral Microinfarcts and Microbleeds in Spontaneous Intracerebral Hemorrhage
| العنوان: | Histopathology of Cerebral Microinfarcts and Microbleeds in Spontaneous Intracerebral Hemorrhage |
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| المؤلفون: | Wilmar M. T. Jolink, Susanne J. van Veluw, Jaco J. M. Zwanenburg, Annemieke J. M. Rozemuller, Wim van Hecke, Matthew P. Frosch, Brian J. Bacskai, Gabriël J. E. Rinkel, Steven M. Greenberg, Catharina J. M. Klijn |
| المساهمون: | Pathology, Amsterdam Neuroscience - Neurodegeneration |
| المصدر: | Translational Stroke Research, 14, 2, pp. 174-184 Jolink, W M T, van Veluw, S J, Zwanenburg, J J M, Rozemuller, A J M, van Hecke, W, Frosch, M P, Bacskai, B J, Rinkel, G J E, Greenberg, S M & Klijn, C J M 2022, ' Histopathology of Cerebral Microinfarcts and Microbleeds in Spontaneous Intracerebral Hemorrhage ', Translational Stroke Research . https://doi.org/10.1007/s12975-022-01016-5 Translational Stroke Research. Springer US Translational Stroke Research, 14, 174-184 |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | All institutes and research themes of the Radboud University Medical Center, nervous system, General Neuroscience, mental disorders, Neurology (clinical), cardiovascular diseases, Cardiology and Cardiovascular Medicine, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], behavioral disciplines and activities, nervous system diseases |
| الوصف: | Contains fulltext : 291431.pdf (Publisher’s version ) (Open Access) In patients with spontaneous intracerebral hemorrhage caused by different vasculopathies, cerebral microinfarcts have the same aspect on MRI and the same applies to cerebral microbleeds. It is unclear what pathological changes underlie these cerebral microinfarcts and cerebral microbleeds. In the current study, we explored the histopathological substrate of these lesions by investigating the brain tissue of 20 patients (median age at death 77 years) who died from ICH (9 lobar, 11 non-lobar) with a combination of post-mortem 7-T MRI and histopathological analysis. We identified 132 CMIs and 204 CMBs in 15 patients on MRI, with higher numbers of CMIs in lobar ICH patients and similar numbers of CMBs. On histopathology, CMIs and CMBs were in lobar ICH more often located in the superficial than in the deep layers of the cortex, and in non-lobar ICH more often in the deeper layers. We found a tendency towards more severe CAA scores in lobar ICH patients. Other histopathological characteristics were comparable between lobar and non-lobar ICH patients. Although CMIs and CMBs were found in different segments of the cortex in lobar ICH compared to non-lobar ICH patients, otherwise similar histopathological features of cortical CMIs and CMBs distant from the ICH suggest shared pathophysiological mechanisms in lobar and non-lobar ICH caused by different vasculopathies. 01 april 2023 |
| وصف الملف: | application/pdf |
| تدمد: | 1868-4483 |
| DOI: | 10.1007/s12975-022-01016-5 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797695ae738c4c698007db135f74df02 https://repository.ubn.ru.nl/handle/2066/291431 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....797695ae738c4c698007db135f74df02 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18684483 |
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| DOI: | 10.1007/s12975-022-01016-5 |