التفاصيل البيبلوغرافية
العنوان:
Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors
المؤلفون:
Hongru Zhang , Pengfei Yu , Vivek S. Tomar , Xiangjie Chen , Matthew J. Atherton , Zhen Lu , Hong-Guang Zhang , Shifeng Li , Angelica Ortiz , Jun Gui , N. Adrian Leu , Fangxue Yan , Andres Blanco , Mirella L. Meyer-Ficca , Ralph G. Meyer , Daniel P. Beiting , Jinyang Li , Selene Nunez-Cruz , Roddy S. O’Connor , Lexus R. Johnson , Andy J. Minn , Subin S. George , Constantinos Koumenis , J. Alan Diehl , Michael C. Milone , Hui Zheng , Serge Y. Fuchs
المصدر:
Nature Cancer . 3:808-820
بيانات النشر:
Springer Science and Business Media LLC, 2022.
سنة النشر:
2022
مصطلحات موضوعية:
Immunosuppression Therapy , Cancer Research , Receptors, Chimeric Antigen , Oncology , Neoplasms , Tumor Microenvironment , Humans , Poly(ADP-ribose) Polymerases , Immunotherapy, Adoptive
الوصف:
Evasion of antitumor immunity and resistance to therapies in solid tumors are aided by an immunosuppressive tumor microenvironment (TME). We found that TME factors, such as regulatory T cells and adenosine, downregulated type I interferon receptor IFNAR1 on CD8
تدمد:
2662-1347
DOI:
10.1038/s43018-022-00383-0
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793f8f3111abf6cd7b393f81929de46e https://doi.org/10.1038/s43018-022-00383-0
Rights:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....793f8f3111abf6cd7b393f81929de46e
قاعدة البيانات:
OpenAIRE