Conditional survival predictions after nephrectomy for renal cell carcinoma
| العنوان: | Conditional survival predictions after nephrectomy for renal cell carcinoma |
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| المؤلفون: | Laurent Zini, Shahrokh F. Shariat, Jean Luc Descotes, Jean Jacques Patard, Nazareno Suardi, Eric Lechevallier, Denis Chautard, Hendrik Isbarn, Luca Cindolo, Umberto Capitanio, Arnaud Mejean, Jacques Tostain, Arie S. Belldegrun, Antoine Valeri, Allan J. Pantuck, Alexandre de la Taille, Vincenzo Ficarra, Herve Lang, Richard Zigeuner, Paul Perrotte, Peter F.A. Mulders, Claudio Jeldres, Maxine Sun, Pierre I. Karakiewicz |
| المساهمون: | Cancer Prognostics and Health Outcome Unit, Université de Montréal (UdeM), Cancer Prognostics and Health Outcomes Unit, Department of urology, Università Vita-Salute San Raffaele, Departement of Oncological and Surgical Sciences, Università degli Studi di Padova = University of Padua (Unipd), Institute of human genetics, Medical University Graz, Service d'Urologie - Andrologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Service d'urologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), G Rummo Hospital, Department of Urology, University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), Hôpital Huriez-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'urologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Département d'Uro-néphro-endocrinologie, CHU Grenoble-Hôpital Michallon, University of Texas Southwestern Medical Center [Dallas], Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Radboud University Medical Center [Nijmegen], Département d'Urologie-Andrologie et Transplantation Rénale [CHU Toulouse], Pôle Urologie - Néphrologie - Dialyse - Transplantations - Brûlés - Chirurgie plastique - Explorations fonctionnelles et physiologiques [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service d'urologie et de transplantation rénale, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM), Service d'urologie [Rennes] = Urology [Rennes], Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Universita degli Studi di Padova, Service d'urologie-andrologie, CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Hôpital nord, University of California-University of California, PRES Université de Toulouse, Service d'urologie [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], De Villemeur, Hervé, CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Hôpital nord, Université de Montréal, CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] ( UJM ) -Hôpital nord, Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Descartes - Paris 5 ( UPD5 ) -CHU Necker - Enfants Malades [AP-HP], University of California at Los Angeles [Los Angeles] ( UCLA ), Hôpital Huriez-Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Université d'Angers ( UA ) -CHU Angers, Université de Brest ( UBO ) -Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille ( APHM ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-CHU Pontchaillou [Rennes] |
| المصدر: | Journal of Urology Journal of Urology, 2009, 182 (6), pp.2607-12. ⟨10.1016/j.juro.2009.08.084⟩ Journal of Urology, Elsevier, 2009, 182 (6), pp.2607-12. ⟨10.1016/j.juro.2009.08.084⟩ Journal of Urology, 182, 6, pp. 2607-12 Journal of Urology, 182, 2607-12 Journal of Urology The Journal of Urology The, 2009, 182 (6), pp.2607-12. 〈10.1016/j.juro.2009.08.084〉 |
| بيانات النشر: | HAL CCSD, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | [ SDV.MHEP.UN ] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Male, Nephrology, [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, medicine.medical_treatment, MESH : Aged, 030232 urology & nephrology, Nephrectomy, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, MESH : Carcinoma, Renal Cell, 0302 clinical medicine, MESH: Aged, 80 and over, MESH : Child, MESH : Nomograms, Renal cell carcinoma, MESH: Child, MESH : Female, [ SDV.MHEP.CHI ] Life Sciences [q-bio]/Human health and pathology/Surgery, Child, Aged, 80 and over, MESH: Aged, MESH : Prognosis, MESH: Middle Aged, MESH: Carcinoma, Renal Cell, MESH : Adult, Middle Aged, Prognosis, Kidney Neoplasms, 3. Good health, MESH: Young Adult, 030220 oncology & carcinogenesis, MESH: Survival Analysis, Female, Adult, medicine.medical_specialty, Adolescent, MESH : Male, Urology, MESH : Young Adult, MESH: Nomograms, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, MESH: Prognosis, Young Adult, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Translational research [ONCOL 3], MESH : Adolescent, Internal medicine, medicine, Carcinoma, Humans, MESH : Middle Aged, MESH : Aged, 80 and over, Carcinoma, Renal Cell, Survival analysis, Aged, MESH: Adolescent, MESH: Humans, Proportional hazards model, business.industry, MESH : Humans, MESH : Nephrectomy, MESH: Adult, Nomogram, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Survival Analysis, MESH : Kidney Neoplasms, MESH: Male, Surgery, MESH: Nephrectomy, Nomograms, MESH : Survival Analysis, MESH: Kidney Neoplasms, business, Kidney cancer, MESH: Female |
| الوصف: | Item does not contain fulltext PURPOSE: Conditional survival implies that on average long-term cancer survivors have a better prognosis than do newly diagnosed individuals. We explored the effect of conditional survival in renal cell carcinoma. MATERIALS AND METHODS: We studied 3,560 patients with renal cell carcinoma of all stages treated with nephrectomy. We applied conditional survival methodology to a previously reported posttreatment nomogram predicting survival after nephrectomy for patients with renal cell carcinoma stage I to IV. We used the same predictor variables that were integrated in the original multivariable Cox regression models, namely TNM stage, Fuhrman grade, tumor size and symptom classification. To validate the conditional survival nomogram we used an independent cohort of 3,560 patients from 15 institutions. RESULTS: The 5-year survival of patients immediately after nephrectomy was 74.2%, which increased to 80.4%, 85.1%, 90.6% and 89.6% at 1, 2, 5 and 10 years after nephrectomy, respectively. The predicted probabilities varied by as much as 50% when, for example, predictions of renal cell carcinoma specific mortality at 10 years were made after nephrectomy vs 5 years later. Within the external validation cohort the accuracy of the conditional nomogram was 89.5%, 90.5%, 88.5% and 86.7% at 1, 2, 5 and 10 years after nephrectomy. CONCLUSIONS: We developed (2,530) and externally validated (3,560) a conditional nomogram for predicting renal cell carcinoma specific mortality that allows consideration of the length of survivorship. Our tool provides the most realistic prognosis estimates with high accuracy. |
| اللغة: | English |
| تدمد: | 0022-5347 |
| DOI: | 10.1016/j.juro.2009.08.084⟩ |
| DOI: | 10.1016/j.juro.2009.08.084〉 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fa8d632172fb8fe42d36c0b5ec78ec https://www.hal.inserm.fr/inserm-00426728 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....78fa8d632172fb8fe42d36c0b5ec78ec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00225347 |
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| DOI: | 10.1016/j.juro.2009.08.084⟩ |