Long-Term Effect of Diabetes and Its Treatment on Cognitive Function
| العنوان: | Long-Term Effect of Diabetes and Its Treatment on Cognitive Function |
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| المؤلفون: | Judith Harth, Patricia A. Cleary, Christopher M. Ryan, William Dahms, Gail Musen, Alan M. Jacobson, Complications Trial, Amanda Burwood, Katie Weinger, Barbara H. Waberski, N. Silvers, Meg Bayless, Diabetes Control |
| المصدر: | New England Journal of Medicine. 356:1842-1852 |
| بيانات النشر: | Massachusetts Medical Society, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, Pediatrics, medicine.medical_specialty, Hypoglycemia, Article, chemistry.chemical_compound, Cognition, Seizures, Diabetes mellitus, Internal medicine, Humans, Hypoglycemic Agents, Insulin, Medicine, Diabetic Coma, Glycated Hemoglobin, Coma, Psychomotor learning, Psychological Tests, Type 1 diabetes, business.industry, General Medicine, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, chemistry, Cohort, Female, Glycated hemoglobin, medicine.symptom, Cognition Disorders, business, Diabetic coma, Follow-Up Studies |
| الوصف: | BACKGROUND Long-standing concern about the effects of type 1 diabetes on cognitive ability has increased with the use of therapies designed to bring glucose levels close to the nondiabetic range and the attendant increased risk of severe hypoglycemia. METHODS A total of 1144 patients with type 1 diabetes enrolled in the Diabetes Control and Complications Trial (DCCT) and its follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study were examined on entry to the DCCT (at mean age 27 years) and a mean of 18 years later with the same comprehensive battery of cognitive tests. Glycated hemoglobin levels were measured and the frequency of severe hypoglycemic events leading to coma or seizures was recorded during the follow-up period. We assessed the effects of original DCCT treatment-group assignment, mean glycated hemoglobin values, and frequency of hypoglycemic events on measures of cognitive ability, with adjustment for age at baseline, sex, years of education, length of follow-up, visual acuity, self-reported sensory loss due to peripheral neuropathy, and (to control for the effects of practice) the number of cognitive tests taken in the interval since the start of the DCCT. RESULTS Forty percent of the cohort reported having had at least one hypoglycemic coma or seizure. Neither frequency of severe hypoglycemia nor previous treatment-group assignment was associated with decline in any cognitive domain. Higher glycated hemoglobin values were associated with moderate declines in motor speed (P=0.001) and psychomotor efficiency (P |
| تدمد: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejmoa066397 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78eb60d4be85d0b7f2131d33d2b95792 https://doi.org/10.1056/nejmoa066397 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....78eb60d4be85d0b7f2131d33d2b95792 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15334406 00284793 |
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| DOI: | 10.1056/nejmoa066397 |