T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis
| العنوان: | T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis |
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| المؤلفون: | Richard T. Robinson |
| المصدر: | mBio mBio, Vol 8, Iss 6 (2017) mBio, Vol 8, Iss 6, p e02087-17 (2017) |
| بيانات النشر: | American Society for Microbiology, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, CD4-Positive T-Lymphocytes, Tuberculosis, mycobacteria, T cell, Biology, CD8-Positive T-Lymphocytes, Microbiology, Mycobacterium tuberculosis, 03 medical and health sciences, Interferon-gamma, Mice, 0302 clinical medicine, Human disease, Immune system, CSF2, T-Lymphocyte Subsets, Virology, medicine, Animals, Humans, Lung, Macrophages, Granulocyte-Macrophage Colony-Stimulating Factor, GM-CSF, medicine.disease, biology.organism_classification, QR1-502, 3. Good health, Experimental tuberculosis, PPAR gamma, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, tuberculosis, Immunology, Commentary, Myelopoiesis, immune, GMCSF, 030215 immunology |
| الوصف: | Although classically associated with myelopoiesis, granulocyte-macrophage colony-stimulating factor (GM-CSF) is increasingly recognized as being important for tuberculosis (TB) resistance. GM-CSF is expressed by nonhematopoietic and hematopoietic lineages following infection with Mycobacterium tuberculosis and is necessary to restrict M. tuberculosis growth in experimental models. Until the recent study by Rothchild et al. (mBio 8:e01514-17, 2017, https://doi.org/10.1128/mBio.01514-17 ), it was unknown whether GM-CSF-producing T cells contribute to TB resistance. Rothchild et al. identify which conventional and nonconventional T cell subsets produce GM-CSF during experimental TB, establish their protective nature using a variety of approaches, and provide a mechanistic basis for their ability to restrict M. tuberculosis growth. This commentary discusses the significance of these findings to basic and applied TB research. As translated to human disease, these findings suggest vaccine-mediated expansion of GM-CSF-producing T cells could be an effective prophylactic or therapeutic TB strategy. |
| اللغة: | English |
| تدمد: | 2150-7511 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d8007be43ae7cdf74be15aeb3cf867 http://europepmc.org/articles/PMC5727419 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....78d8007be43ae7cdf74be15aeb3cf867 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21507511 |
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