Genetic predictors of severe intraventricular hemorrhage in extremely low-birthweight infants
| العنوان: | Genetic predictors of severe intraventricular hemorrhage in extremely low-birthweight infants |
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| المؤلفون: | Brenda B. Poindexter, Stephen W. Erickson, M Elizabeth Hartnett, Courtney D. Thornburg, Abhik Das, Erin A.S. Clark, Ricki F. Goldstein, John M. Dagle, Grier P. Page, C. Michael Cotten, Margaret M. DeAngelis, Jeffrey C. Murray |
| المصدر: | J Perinatol |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, Single-nucleotide polymorphism, Infant, Premature, Diseases, Organ development, Logistic regression, Article, Child health, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, medicine, Birth Weight, Humans, 030212 general & internal medicine, Child, Genotyping, Cerebral Hemorrhage, business.industry, Infant, Newborn, Genetic variants, Infant, Obstetrics and Gynecology, medicine.disease, Neurovascular bundle, Intraventricular hemorrhage, nervous system, Infant, Extremely Low Birth Weight, Pediatrics, Perinatology and Child Health, business, Infant, Premature |
| الوصف: | OBJECTIVE: To test associations between grades 3 or 4 (severe) intraventricular hemorrhage (IVH) and single nucleotide polymorphisms (SNPs) associated with coagulation, inflammation, angiogenesis, and organ development in an exploratory study. STUDY DESIGN: Extremely low-birthweight (ELBW) infants enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network’s (NRN) Cytokines Study were included if they had cranial ultrasound (CUS) and genotyping data available in the NRN Anonymized DNA Repository and Database. Associations between SNPs and IVH severity were tested with multivariable logistic regression analysis. RESULT: One hundred thirty-nine infants with severe IVH and 687 infants with grade 1 or 0 IVH were included. One thousand two hundred seventy-nine SNPs were genotyped. Thirteen were preliminarily associated with severe IVH including five related to central nervous system (CNS) neuronal and neurovascular development. CONCLUSION: Genetic variants for CNS neuronal and neurovascular development may be associated with severe IVH in premature infants. |
| تدمد: | 1476-5543 0743-8346 |
| DOI: | 10.1038/s41372-020-00821-w |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78abb56c7301dc9ada4704a142f7b348 https://doi.org/10.1038/s41372-020-00821-w |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....78abb56c7301dc9ada4704a142f7b348 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765543 07438346 |
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| DOI: | 10.1038/s41372-020-00821-w |