Xenotransplantation—the current status and prospects
| العنوان: | Xenotransplantation—the current status and prospects |
|---|---|
| المؤلفون: | Alfred Joseph Tector, Devin E. Eckhoff, Hayato Iwase, Robert S. Gaston, Liaoran Wang, Joseph M. Ladowski, Matthew Tector, Takayuki Yamamoto, David K. C. Cooper, Hidetaka Hara |
| المصدر: | British Medical Bulletin. 125:5-14 |
| بيانات النشر: | Oxford University Press (OUP), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Swine, Xenotransplantation, medicine.medical_treatment, Transplantation, Heterologous, Economic shortage, Disease, 030230 surgery, Animals, Genetically Modified, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Intensive care medicine, Invited Review, business.industry, Potential risk, Genetically engineered, Graft Survival, General Medicine, Genetically modified organism, Clinical trial, Transplantation, 030104 developmental biology, Tissue and Organ Harvesting, Heterografts, business |
| الوصف: | Introduction There is a continuing worldwide shortage of organs from deceased human donors for transplantation into patients with end-stage organ failure. Genetically engineered pigs could resolve this problem, and could also provide tissues and cells for the treatment of conditions such as diabetes, Parkinson's disease and corneal blindness. Sources of data The current literature has been reviewed. Areas of agreement The pathobiologic barriers are now largely defined. Research progress has advanced through the increasing availability of genetically engineered pigs and novel immunosuppressive agents. Life-supporting pig kidneys and islets have functioned for months or years in nonhuman primates. Areas of controversy The potential risk of transfer of a pig infectious microorganism to the recipient continues to be debated. Growing points Increased attention is being paid to selection of patients for initial clinical trials. Areas timely for developing research Most of the advances required to justify a clinical trial have now been met. |
| تدمد: | 1471-8391 0007-1420 |
| DOI: | 10.1093/bmb/ldx043 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7888be30d015b306fb3ae0d110e4239b https://doi.org/10.1093/bmb/ldx043 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7888be30d015b306fb3ae0d110e4239b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14718391 00071420 |
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| DOI: | 10.1093/bmb/ldx043 |