ABCA1 polymorphisms and Alzheimer's disease
| العنوان: | ABCA1 polymorphisms and Alzheimer's disease |
|---|---|
| المؤلفون: | Fabienne Wavrant-De Vrièze, Ling Li, Meridith Womick, Jordi Pérez-Tur, Omanma Adighibe, Sampath Arepalli, Danielle Compton, John Hardy |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Elsevier BV, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, Linkage disequilibrium, Genotype, ABCA1, Locus (genetics), Chromosome 9, Disease, Biology, Article, Linkage Disequilibrium, Alzheimer Disease, Risk Factors, Genetic variation, medicine, Humans, Genetic Predisposition to Disease, Aged, Genetics, General Neuroscience, Haplotype, medicine.disease, Pedigree, Haplotypes, ATP-Binding Cassette Transporters, Female, lipids (amino acids, peptides, and proteins), Alzheimer's disease, Polymorphisms, Alzheimer’s disease, Polymorphism, Restriction Fragment Length, ATP Binding Cassette Transporter 1 |
| الوصف: | Final full-text version of the paper available at: http://ees.elsevier.com/nsl/. Copyright © by Elsevier. In our search for genetic factors related to the development of Alzheimer’s disease, we have genotyped 332 pedigrees for 3 coding polymorphisms in the ABCA1 gene, two of which are known to alter plasma cholesterol levels, as well as a non-coding polymorphism within the promoter. We show an apparent weak association of rs2230806 (p-value= 0.01) with the disease in a sibpair series of Alzheimer’s disease that had shown previously evidence for linkage to the chromosome 9 locus where ABCA1 maps. This work was supported by the NIA/NIH intramural research program. Many data and biomaterials were collected by the NCRAD (grant number U24 AG21886), as well as the National Institute of Mental Health (NIMH) Alzheimer’s Disease Genetics Initiative (grants numbers U01 MH46281, U01 MH46290, U01 MH46373). |
| وصف الملف: | 66291 bytes; application/pdf |
| تدمد: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2007.02.010 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786d60fd659b8a9bc0a40fa420e70bfc https://doi.org/10.1016/j.neulet.2007.02.010 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....786d60fd659b8a9bc0a40fa420e70bfc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03043940 |
|---|---|
| DOI: | 10.1016/j.neulet.2007.02.010 |