Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes
| العنوان: | Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes |
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| المؤلفون: | David G. Kugler, Dragana Jankovic, Olena Kamenyeva, Diego L. Costa, Stephan P. Rosshart, Alan Sher, Barbara Rehermann, Francis A. Flomerfelt, Karen Laky, Jonathan D. Ashwell, Paul R. Mittelstadt, Ronald E. Gress |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | The Rockefeller University Press, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Senescence, CD4-Positive T-Lymphocytes, Immunology, Thymus Gland, Biology, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, parasitic diseases, medicine, Immunology and Allergy, Animals, Pathogen, Research Articles, Mice, Knockout, Mice, Inbred BALB C, Effector, Toxoplasma gondii, T lymphocyte, biology.organism_classification, medicine.disease, Toxoplasmosis, 030104 developmental biology, Lymphatic system, Toxoplasma, 030215 immunology |
| الوصف: | Kugler et al. show that systemic infection with Toxoplasma gondii triggers a long-term impairment in thymic function, which leads to an immunodeficient state reflected in decreased antimicrobial resistance. Because antigen-stimulated naive T cells either die as effectors or enter the activated/memory pool, continuous egress of new T lymphocytes from thymus is essential for maintenance of peripheral immune homeostasis. Unexpectedly, we found that systemic infection with the protozoan Toxoplasma gondii triggers not only a transient increase in activated CD4+ Th1 cells but also a persistent decrease in the size of the naive CD4+ T lymphocyte pool. This immune defect is associated with decreased thymic output and parasite-induced destruction of the thymic epithelium, as well as disruption of the overall architecture of that primary lymphoid organ. Importantly, the resulting quantitative and qualitative deficiency in naive CD4+ T cells leads to an immunocompromised state that both promotes chronic toxoplasma infection and leads to decreased resistance to challenge with an unrelated pathogen. These findings reveal that systemic infectious agents, such as T. gondii, can induce long-term immune alterations associated with impaired thymic function. When accumulated during the lifetime of the host, such events, even when occurring at low magnitude, could be a contributing factor in immunological senescence. |
| اللغة: | English |
| تدمد: | 1540-9538 0022-1007 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7819efbb8fed3fb6b0de97bfb79820f1 http://europepmc.org/articles/PMC5154934 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7819efbb8fed3fb6b0de97bfb79820f1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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