Brevisulcenals-A1 and A2, Sulfate Esters of Brevisulcenals, Isolated from the Red Tide Dinoflagellate Karenia brevisulcata
| العنوان: | Brevisulcenals-A1 and A2, Sulfate Esters of Brevisulcenals, Isolated from the Red Tide Dinoflagellate Karenia brevisulcata |
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| المؤلفون: | Yoshiyuki Itoh, Raku Irie, Patrick T. Holland, Fumiaki Hayashi, D. Tim Harwood, Feng Shi, Masayuki Satake, Huiping Zhang |
| المصدر: | Toxins, Vol 13, Iss 82, p 82 (2021) Toxins Volume 13 Issue 2 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0106 biological sciences, Karenia brevisulcata, Chromatography, biology, 010604 marine biology & hydrobiology, Health, Toxicology and Mutagenesis, Red tide, lcsh:R, Dinoflagellate, lcsh:Medicine, Ether, 010402 general chemistry, Toxicology, biology.organism_classification, Tandem mass spectrometry, dinoflagellate, 01 natural sciences, marine polyether, 0104 chemical sciences, chemistry.chemical_compound, Sulfation, chemistry, red tide incident, Sulfate, harmful algal bloom |
| الوصف: | Two different types of polycyclic ether toxins, namely brevisulcenals (KBTs) and brevisulcatic acids (BSXs), produced by the red tide dinoflagellate Karenia brevisulcata, were the cause of a toxic incident that occurred in New Zealand in 1998. Four major components, KBT-F, -G, -H, and -I, shown to be cytotoxic and lethal in mice, were isolated from cultured K. brevisulcata cells, and their structures were elucidated by spectroscopic analyses. New analogues, brevisulcenal-A1 (KBT-A1) and brevisulcenal-A2 (KBT-A2), toxins of higher polarity than that of known KBTs, were isolated from neutral lipophilic extracts of bulk dinoflagellate culture extracts. The structures of KBT-A1 and KBT-A2 were elucidated as sulfated analogues of KBT-F and KBT-G, respectively, by NMR and matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI TOF/TOF), and by comparison with the spectra of KBT-F and KBT-G. The cytotoxicities of the sulfate analogues were lower than those of KBT-F and KBT-G. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6651 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7806ab055946eed00e1cba6a456652c1 https://www.mdpi.com/2072-6651/13/2/82 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7806ab055946eed00e1cba6a456652c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726651 |
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