G-Quadruplexes in the Archaea Domain
| العنوان: | G-Quadruplexes in the Archaea Domain |
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| المؤلفون: | Hannu Myllykallio, Violette Da Cunha, Miroslav Fojta, Martin Bartas, Otília Porubiaková, Jean-Louis Mergny, Václav Brázda, Patrick Forterre, Petr Pečinka, Jiří Šťastný, Daniela Verga, Tomio S. Takahashi, Patrik Kaura, Yu Luo |
| المساهمون: | Centre National de la Recherche Scientifique (CNRS), Chimie et modélisation pour la biologie du cancer (CMBC), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institute of Biophysics of the Czech Academy of Sciences (IBP / CAS), Czech Academy of Sciences [Prague] (CAS), Ostravská univerzita / University of Ostrava, Brno University of Technology [Brno] (BUT), Mendel University in Brno (MENDELU), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Biologie Cellulaire des Archées (ARCHEE), Département Microbiologie (Dpt Microbio), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Optique et Biosciences (LOB), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École polytechnique (X), École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Mergny, Jean-Louis |
| المصدر: | Biomolecules Biomolecules, MDPI, 2020, 10 (9), pp.1349. ⟨10.3390/biom10091349⟩ Biomolecules, MDPI, 2020, 10 (9), pp.E1349. ⟨10.3390/biom10091349⟩ Biomolecules, Vol 10, Iss 1349, p 1349 (2020) Biomolecules, 2020, 10 (9), pp.E1349. ⟨10.3390/biom10091349⟩ Biomolecules. 2020, vol. 10, issue 9, p. 1-23. Volume 10 Issue 9 |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | G4-forming motif, Archaeal Proteins, [SDV]Life Sciences [q-bio], lcsh:QR1-502, Computational biology, Biology, G-quadruplex, Biochemistry, Genome, Article, lcsh:Microbiology, sequence prediction, 03 medical and health sciences, chemistry.chemical_compound, Species Specificity, Genome, Archaeal, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, heterocyclic compounds, Molecular Biology, Phylogeny, 030304 developmental biology, genome analysis, 0303 health sciences, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Domain (biology), Phylum, Circular Dichroism, 030302 biochemistry & molecular biology, RNA, DNA, Genomics, Non-coding RNA, biology.organism_classification, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Archaea, DNA-Binding Proteins, G-Quadruplexes, chemistry, unusual nucleic acid structures, Nucleic Acid Conformation |
| الوصف: | International audience; The importance of unusual DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) have gained in popularity during the last decade, and their presence and functional relevance at the DNA and RNA level has been demonstrated in a number of viral, bacterial, and eukaryotic genomes, including humans. Here, we performed the first systematic search of G4-forming sequences in all archaeal genomes available in the NCBI database. In this article, we investigate the presence and locations of G-quadruplex forming sequences using the G4Hunter algorithm. G-quadruplex-prone sequences were identified in all archaeal species, with highly significant differences in frequency, from 0.037 to 15.31 potential quadruplex sequences per kb. While G4 forming sequences were extremely abundant in Hadesarchaea archeon (strikingly, more than 50% of the Hadesarchaea archaeon isolate WYZ-LMO6 genome is a potential part of a G4-motif), they were very rare in the Parvarchaeota phylum. The presence of G-quadruplex forming sequences does not follow a random distribution with an over-representation in non-coding RNA, suggesting possible roles for ncRNA regulation. These data illustrate the unique and non-random localization of G-quadruplexes in Archaea. |
| وصف الملف: | application/pdf; text |
| اللغة: | English |
| تدمد: | 2218-273X |
| DOI: | 10.3390/biom10091349⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77af900d1a21559003ff62ff5ea30604 https://hal.archives-ouvertes.fr/hal-03028241/file/biomolecules-10-01349-v2.pdf |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....77af900d1a21559003ff62ff5ea30604 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2218273X |
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| DOI: | 10.3390/biom10091349⟩ |