Microbiological and biochemical findings in relation to clinical periodontal status in active smokers, non-smokers and passive smokers
| العنوان: | Microbiological and biochemical findings in relation to clinical periodontal status in active smokers, non-smokers and passive smokers |
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| المؤلفون: | Burcu Kanmaz, Himabindu Gogeneni, Nurcan Buduneli, David A. Scott, Gwyneth J. Lamont, Gulcan Danaci |
| المساهمون: | Ege Üniversitesi |
| المصدر: | Tobacco Induced Diseases Tobacco Induced Diseases, Vol 17, Iss March (2019) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Saliva, Health (social science), Bleeding on probing, Medicine (miscellaneous), environmental tobacco smoke, Disease, lcsh:RC254-282, Gastroenterology, Tobacco smoke, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, bacteria, Porphyromonas gingivalis, lcsh:RC705-779, Periodontitis, saliva, biology, business.industry, Public Health, Environmental and Occupational Health, matrix metalloproteinases, Treponema denticola, lcsh:Diseases of the respiratory system, 030206 dentistry, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, biology.organism_classification, cytokines, respiratory tract diseases, stomatognathic diseases, 030104 developmental biology, chemistry, behavior and behavior mechanisms, medicine.symptom, business, Cotinine, Research Paper |
| الوصف: | WOS: 000465426600005 PubMed ID: 31582931 INTRODUCTION Cigarette users are more susceptible than non-smokers to periodontitis, a bacterial-induced, inflammation-driven, destructive disease of the supporting tissues of the teeth. We hypothesized that clinical periodontal findings and microbiological and/or inflammatory marker levels would be intermediate in those exposed to environmental tobacco smoke compared to active smokers and non-smokers. METHODS Sixty individuals were recruited from a University periodontal clinic and assigned as non-smokers, active smokers or passive-smokers according to their self reports. Clinical periodontal measurements, comprising plaque index, probing depth (PD), clinical attachment level (CAL) and bleeding on probing, were recorded at six sites per tooth. Cotinine levels were determined in whole saliva samples by EIA. Treponema denticola and Porphyromonas gingivalis infection was determined by PCR, while matrix metalloproteinase-8 (MMP-8) and interleukin-8 (IL-8) concentrations were determined by ELISA. RESULTS Study groups were subsequently reassigned in accordance with the cotinine data. The smoker group exhibited higher mean PD and CAL values compared to the non-smoker group (p0.05). CONCLUSIONS The present clinical periodontal findings provide further support for a negative, dose-related effect of tobacco exposure on periodontal health. The tendency for a more prevalent detection of T. denticola and for a suppressed inflammatory response observed in the smokers may partly explain the increased susceptibility to periodontal tissue destruction, but needs to be verified in larger scale studies. Ege UniversityEge University; Louisville University This study was funded by Ege University and Louisville University. |
| تدمد: | 1617-9625 3158-2931 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776470f7c5206dbafe422030ba879f1a https://pubmed.ncbi.nlm.nih.gov/31582931 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....776470f7c5206dbafe422030ba879f1a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16179625 31582931 |
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