Organic Compound with Potential for X‑ray Imaging Applications
| العنوان: | Organic Compound with Potential for X‑ray Imaging Applications |
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| المؤلفون: | K Kezia Susan, E R Jayadevan, Roy Joseph, Gopika V Gopan |
| المصدر: | ACS Omega, Vol 6, Iss 38, Pp 24826-24833 (2021) ACS Omega |
| بيانات النشر: | American Chemical Society, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | chemistry.chemical_classification, General Chemical Engineering, Hypochlorite, General Chemistry, Organic compound, Article, chemistry.chemical_compound, Chemistry, chemistry, Bromide, Sodium hypochlorite, Sodium iodide, Diphenolic acid, Fourier transform infrared spectroscopy, Spectroscopy, QD1-999, Nuclear chemistry |
| الوصف: | A radiopaque compound, namely, 4,4-bis(4-hydroxy-3,5-diiodophenyl)pentanoic acid, was synthesized by the electrophilic aromatic iodination of 4,4-bis(4-hydroxyphenyl)pentanoic acid using sodium iodide and sodium hypochlorite. The active iodines created by hypochlorite were selectively bound to the ortho positions of the diphenolic acid and obtained a tetraiodo compound. Characterization of this iodinated compound was accomplished by routine methods such as Fourier transform infrared (FTIR) spectroscopy, 1H nuclear magnetic resonance (NMR) spectroscopy, energy-dispersive X-ray spectroscopy, mass spectroscopy, UV-Vis spectroscopy, and thermogravimetry. The iodine content in the compound was as high as 64% by weight and therefore expected to possess substantial radiopacity. A 5% solution of the compound in dimethyl sulfoxide exhibited radiopacity of 885 ± 7 Hounsfield Units when tested with computed tomography (CT) scanner. In vitro cytotoxicity test performed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay demonstrated that the compound was noncytotoxic to L929 fibroblast cells up to the level of 0.8 mg/mL concentration. Overall results indicate that this highly radiopaque compound has the potential to be used for X-ray imaging in the clinical scenario. |
| اللغة: | English |
| تدمد: | 2470-1343 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d22eeb1f181078c8369d4a9621c001 https://doaj.org/article/d8dbcf4e18ab4cb7a048def0dfb48427 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....76d22eeb1f181078c8369d4a9621c001 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24701343 |
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