High consumption of smokeless tobacco ('snus') predicts increased risk of type 2 diabetes in a 10-year prospective study of middle-aged Swedish men
| العنوان: | High consumption of smokeless tobacco ('snus') predicts increased risk of type 2 diabetes in a 10-year prospective study of middle-aged Swedish men |
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| المؤلفون: | Valdemar Grill, Claes-Göran Östenson, Agneta Hilding, Suad Efendic |
| المصدر: | Scandinavian Journal of Public Health. 40:730-737 |
| بيانات النشر: | SAGE Publications, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Moist snuff, Tobacco, Smokeless, endocrine system diseases, Dentistry, Type 2 diabetes, Risk Assessment, Environmental health, Odds Ratio, Humans, Medicine, Prospective Studies, Prospective cohort study, Sweden, Consumption (economics), Harm reduction, business.industry, Incidence, Public Health, Environmental and Occupational Health, nutritional and metabolic diseases, General Medicine, Glucose Tolerance Test, Middle Aged, medicine.disease, Increased risk, Diabetes Mellitus, Type 2, Smokeless tobacco, Snus, business, Follow-Up Studies |
| الوصف: | Aims: Cigarette smoking increases the risk of type 2 diabetes (T2D). In Sweden and the US, people shift from smoking cigarettes to smokeless tobacco, i.e. oral moist snuff, “snus”, to attain harm-reduction. There are limited and conflicting data as to whether snus increases the risk of T2D. The present study investigated if snus use predicts the risk of T2D incidence. Methods: This is a prospective population-based study where middle-aged Swedish men ( n=2,383), without previously diagnosed T2D, were investigated with oral glucose tolerance test (OGTT) at baseline in 1992–94 and at follow-up 10 years later. Odds ratios (ORs) for newly diagnosed T2D at follow-up were assessed among those using snus, or cigarettes, at both baseline and follow-up, adjusted for major confounders. Results: The OR for T2D was not significantly increased in the whole group of snus users. However, the risk of diabetes increased with increasing weekly snus consumption; ORs (CIs) for >four boxes of snus/week were 2.1 (CI 0.9–4.9), and for >five boxes/week 3.3 (CI 1.4–8.1). For comparison, men smoking at baseline and still smoking at follow-up had an increased risk of diabetes compared with never smokers, OR 1.5 (CI 0.8–3.0), most evident for those smoking >15 cigarettes per day, OR 2.4 (CI 1.0–5.8). Tobacco use was associated with estimations of low insulin response (OGTT), but not low insulin sensitivity (HOMA). Conclusions: High consumption of snus, like smoking, predicts risk of developing T2D. This should be considered when seeking harm-reduction by changing from use of cigarettes to snus. T2D risk from tobacco use may be mediated by effects on beta-cell function. |
| تدمد: | 1651-1905 1403-4948 |
| DOI: | 10.1177/1403494812459814 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cc92688c36a1490da5e84dae2f0ca7 https://doi.org/10.1177/1403494812459814 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....76cc92688c36a1490da5e84dae2f0ca7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16511905 14034948 |
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| DOI: | 10.1177/1403494812459814 |