Impact of p16INK4a Immunohistochemistry Staining on Interobserver Agreement on the Diagnosis of Cervical Intraepithelial Neoplasia
| العنوان: | Impact of p16INK4a Immunohistochemistry Staining on Interobserver Agreement on the Diagnosis of Cervical Intraepithelial Neoplasia |
|---|---|
| المؤلفون: | Ilaria Sabatucci, Roberto Pisa, Vincenzo Maccallini, Paolo Giorgi Rossi, B. Ghiringhello, Alberto Pacchiarotti, Simona Galeotti, Giovanni Negri, Fabio Musolino, Paola Bellardini, Guido Collina, Paolo Palma, Francesco Chini |
| المصدر: | American Journal of Clinical Pathology. 141:367-373 |
| بيانات النشر: | Oxford University Press (OUP), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Population, Uterine Cervical Neoplasms, Cervical intraepithelial neoplasia, Biopsy, Biomarkers, Tumor, medicine, Humans, education, Cyclin-Dependent Kinase Inhibitor p16, Mass screening, Observer Variation, Gynecology, Colposcopy, Cervical cancer, education.field_of_study, medicine.diagnostic_test, business.industry, Reproducibility of Results, General Medicine, Middle Aged, Uterine Cervical Dysplasia, medicine.disease, Immunohistochemistry, Confidence interval, Staining, Female, Nuclear medicine, business |
| الوصف: | This study aimed to compare the interobserver Cohen κ on HE staining and on HE plus p16(INK4a) staining of all cervical biopsy specimens in a population-based screening program.All the colposcopy-guided biopsies generated by the routine screening of 23,258 women aged 25 to 64 years were stained with HE and HE plus p16. Biopsy specimens were reviewed by six external experts.The four diagnoses were available in 441 cases. The interobserver κ values were 0.52 (95% confidence interval [CI], 0.45-0.58) and 0.48 (95% CI, 0.42-0.56) with HE and HE + p16, respectively, when using a five-group classification (normal, CIN 1, CIN 2, CIN 3, and cancer); adopting a two-group classification (≤CIN 1 and ≥CIN 2), the values were 0.75 (95% CI, 0.66-0.82) and 0.70 (95% CI, 0.61-0.79), respectively.The use of p16 on all cervical biopsy specimens in a screening program showed virtually no effect on reproducibility of the histologic diagnosis. |
| تدمد: | 1943-7722 0002-9173 |
| DOI: | 10.1309/ajcpcywvl61svkfu |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c1072aa8dba72377a8bf1fcdb8f486 https://doi.org/10.1309/ajcpcywvl61svkfu |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....76c1072aa8dba72377a8bf1fcdb8f486 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19437722 00029173 |
|---|---|
| DOI: | 10.1309/ajcpcywvl61svkfu |