The outcome of bifurcation lesion stenting using a biolimus-eluting stent with a bio-degradable polymer compared to a sirolimus-eluting stent with a durable polymer
| العنوان: | The outcome of bifurcation lesion stenting using a biolimus-eluting stent with a bio-degradable polymer compared to a sirolimus-eluting stent with a durable polymer |
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| المؤلفون: | Bernhard Meier, Ton de Vries, Joanna J. Wykrzykowska, Pedro Eerdmans, Peter Jüni, Carlo Di Mario, Stanislaw Trznadel, Karsten Lenk, Robert-Jan van Geuns, Paweł Buszman, Stephan Windecker, Paweł Tyczyński, Gerrit-Anne van Es, Volker Klauss, Franz R. Eberli, Thomas Ischinger, Roberto Corti, Scot Garg, Marie-Claude Morice, Axel Linke, Patrick W. Serruys, William Wijns |
| المساهمون: | Cardiology, Radiology & Nuclear Medicine, University of Zurich |
| المصدر: | EuroIntervention, 6(8), 928-935. EuroPCR Garg, Scot; Wykrzykowska, Joanna; Serruys, Patrick W; de Vries, Ton; Buszman, Pawel; Trznadel, Stanislaw; Linke, Axel; Lenk, Karsten; Ischinger, Thomas; Klauss, Volker; Eberli, Franz; Corti, Roberto; Wijns, William; Morice, Marie-Claude; di Mario, Carlo; Tyczynski, Pawel; van Geuns, Robert Jan; Eerdmans, Pedro; van Es, Gerrit-Anne; Meier, Bernhard; ... (2011). The outcome of bifurcation lesion stenting using a biolimus-eluting stent with a bio-degradable polymer compared to a sirolimus-eluting stent with a durable polymer. EuroIntervention, 6(8), pp. 928-935. Toulouse: Europa Digital & Publishing |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Polymers, medicine.medical_treatment, Myocardial Infarction, 610 Medicine & health, Coronary Artery Disease, Kaplan-Meier Estimate, 2705 Cardiology and Cardiovascular Medicine, Internal medicine, Durable polymer, Absorbable Implants, Clinical endpoint, Medicine, Humans, Myocardial infarction, cardiovascular diseases, Acute Coronary Syndrome, Angioplasty, Balloon, Coronary, Aged, Sirolimus, Protein synthesis inhibitor, business.industry, Stent, Drug-Eluting Stents, Middle Aged, medicine.disease, equipment and supplies, Surgery, surgical procedures, operative, Treatment Outcome, Drug-eluting stent, Cardiology, 10209 Clinic for Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Mace, medicine.drug, Follow-Up Studies |
| الوصف: | Aims: This study investigated the differences in clinical outcomes between patients with bifurcation lesions (BL) treated with a biolimus-eluting stent (BES) with a biodegradable polymer, and a sirolimus-eluting stent (SES) with a durable polymer. Methods and results: The clinical outcomes were assessed in the 497 patients (BES 258, SES 239) enrolled in the multicentre, randomised LEADERS trial who underwent treatment of Y1 BL (total=534 BL). At 12-months follow-up there was no significant difference in the primary endpoint of MACE, a composite of cardiac death, myocardial infarction and clinically indicated target vessel revascularisation (BES 12.8% vs. SES 16.3%, p=0.31). Patients treated with BES had comparable rates of cardiac death (BES 2.7% vs. SES 2.9%, p=1.00), numerically higher rates of myocardial infarction (BES 8.9% vs. SES 5.4%, p=0.17), and significantly lower rates of clinically indicated target vessel revascularisation (4.3% vs. 11.3%, p=0.004) when compared to those treated with SES. The rate of stent thrombosis at 12-months was 4.3% and 3.8% for BES and SES, respectively (p=0.82). Conclusions: In the treatment of BL the use of BES lead to superior efficacy and comparable safety compared to SES. © Europa Edition 2011. All rights reserved. |
| وصف الملف: | application/pdf |
| تدمد: | 1774-024X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7650bc0806fcfeea50a5cf38d8bc7f44 https://pure.eur.nl/en/publications/f73465f1-bd16-4c3c-b786-df96ac4cd53e |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7650bc0806fcfeea50a5cf38d8bc7f44 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1774024X |
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