Patterns of surveillance for late effects of BCR-ABL tyrosine kinase inhibitors in survivors of pediatric Philadelphia chromosome positive leukemias
| العنوان: | Patterns of surveillance for late effects of BCR-ABL tyrosine kinase inhibitors in survivors of pediatric Philadelphia chromosome positive leukemias |
|---|---|
| المؤلفون: | John Bergsagel, Stephanie M. Smith, Rebecca Williamson Lewis, Kathleen M. Sakamoto, Himalee S. Sabnis, Briana C. Patterson, Sharon M. Castellino, Lidia Schapira, Ann C. Mertens, Karen E. Effinger |
| المصدر: | BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021) BMC Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_treatment, Dasatinib, Fusion Proteins, bcr-abl, Late-effects, Thyrotropin, Ph + ALL, Electrocardiography, Absorptiometry, Photon, 0302 clinical medicine, Cancer Survivors, Surgical oncology, hemic and lymphatic diseases, Philadelphia Chromosome, Molecular Targeted Therapy, Child, CML, RC254-282, Surveillance, Philadelphia Chromosome Positive, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Myeloid leukemia, Leukemia, Echocardiography, Population Surveillance, 030220 oncology & carcinogenesis, Imatinib Mesylate, Female, Research Article, medicine.medical_specialty, Bcr-abl leukemia, Adolescent, 03 medical and health sciences, Age Determination by Skeleton, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Internal medicine, Survivorship curve, Genetics, medicine, Humans, Protein Kinase Inhibitors, Retrospective Studies, Tyrosine kinase inhibitors, Chemotherapy, business.industry, Bone age, medicine.disease, 030104 developmental biology, Concomitant, business |
| الوصف: | Background Targeted anticancer therapies such as BCR-ABL tyrosine kinase inhibitors (TKIs) have improved outcomes for chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL). However, little is known about long-term risks of TKIs in children. Exposure-based survivorship guidelines do not include TKIs, thus surveillance practices may be variable. Methods We retrospectively examined surveillance for cardiac and endocrine late effects in children receiving TKIs for Ph + leukemias, diagnosed at Results 66 patients (CML n = 44; Ph + ALL n = 22) met inclusion criteria. Among patients with CML, ≥1 evaluation was done: ECHO (50.0%), EKG (48.8%), TSH (43.9%), DXA (2.6%), bone age (7.4%). Among patients with Ph + ALL, ≥1 evaluation was done: ECHO (86.4%), EKG (68.2%), TSH (59.1%), DXA (63.6%), bone age (44.4%). Over a median 6.3 and 5.7 years of observation, respectively, 2% of patients with CML and 57% with Ph + ALL attended a survivorship clinic. Conclusions Despite common exposure to TKIs in survivors of Ph + leukemias, patterns of surveillance for late effects differed in CML and Ph + ALL, with the latter receiving more surveillance likely due to concomitant chemotherapy exposures. Targeted therapies such as TKIs are revolutionizing cancer treatment, but surveillance for late effects and referral to survivorship clinics are variable despite the chronicity of exposure. Evidence based guidelines and longer follow-up are needed. |
| تدمد: | 1471-2407 |
| DOI: | 10.1186/s12885-021-08182-z |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a533166edcc9c743d808d6fe0f8b27 https://doi.org/10.1186/s12885-021-08182-z |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....75a533166edcc9c743d808d6fe0f8b27 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712407 |
|---|---|
| DOI: | 10.1186/s12885-021-08182-z |