RELATIONSHIP BETWEEN SELENIUM NUTRITIONAL STATUS AND MARKERS OF LOW-GRADE CHRONIC INFLAMMATION IN OBESE WOMEN
| العنوان: | RELATIONSHIP BETWEEN SELENIUM NUTRITIONAL STATUS AND MARKERS OF LOW-GRADE CHRONIC INFLAMMATION IN OBESE WOMEN |
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| المؤلفون: | Larissa Cristina Fontenelle, Mickael de Paiva Sousa, Loanne Rocha dos Santos, Bruna Emanuele Pereira Cardoso, Thayanne Gabryelle Visgueira de Sousa, Tamires da Cunha Soares, Stéfany Rodrigues de Sousa Melo, Jennifer Beatriz Silva Morais, Thaline Milany da Silva Dias, Francisco Erasmo de Oliveira, Débora Cavalcante Braz, João Marcelo de Castro e Sousa, Francisco Leonardo Torres-Leal, Gilberto Simeone Henriques, Dilina do Nascimento Marreiro |
| المصدر: | Biological Trace Element Research. 201:663-676 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Inorganic Chemistry, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, General Medicine, Biochemistry |
| الوصف: | Low-grade chronic inflammation is one of the main disorders that characterize adipose tissue dysfunction in obesity and is an important element in the pathogenesis of several comorbidities. In this context, selenium is an essential micronutrient that exerts important anti-inflammatory functions, and the role of selenium in controlling inflammation associated with obesity is not well defined. Thus, this study aimed to evaluate the relationship between markers of the nutritional status of selenium and low-grade chronic inflammation in obese women. This cross-sectional study included 81 women aged between 18 and 50 years, who were divided into two groups according to body mass index (BMI): the obesity group (n = 38) and normal weight group (n = 43). Selenium intake was assessed by 3-day diet records. The plasma, erythrocyte, and urinary selenium concentrations were determined using inductively coupled plasma optical emission spectrometry. The analysis of serum cytokines interleukin (IL)-8, IL-1β, IL-6, IL-10, and tumor necrosis factor alpha (TNFα) was performed using flow cytometry. The results of this study revealed that the obese women had higher dietary intake of selenium than eutrophic women. However, obese participants showed decreased selenium concentrations in plasma and erythrocytes, in parallel with increased concentrations of selenium in the urine. Regarding the inflammatory parameters, obese women exhibited higher concentrations of IL-6 and lower concentrations of the cytokines IL-8, IL-1β, and TNFα than eutrophic women. In the binary logistic regression analysis, erythrocyte selenium was considered an independent predictor of the serum concentrations of cytokine IL-8 in obese women, reflecting the anti-inflammatory action of this micronutrient. |
| تدمد: | 1559-0720 0163-4984 |
| DOI: | 10.1007/s12011-022-03209-3 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755f9871d4f8e295154f6a7583099a4c https://doi.org/10.1007/s12011-022-03209-3 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....755f9871d4f8e295154f6a7583099a4c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590720 01634984 |
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| DOI: | 10.1007/s12011-022-03209-3 |