The role of Aggregatibacter actinomycetemcomitans and its leukotoxin in periodontitis
| العنوان: | The role of Aggregatibacter actinomycetemcomitans and its leukotoxin in periodontitis |
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| المؤلفون: | Carola Höglund Åberg, Rolf Claesson, Mark Lindholm, Jan Oscarsson, Anders Johansson |
| المصدر: | Journal of Oral Microbiology, Vol 9, Iss 0 (2017) Journal of Oral Microbiology |
| بيانات النشر: | Taylor & Francis Group, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Microbiology (medical), Serotype, biology, Operon, Aggregatibacter actinomycetemcomitans, lcsh:QR1-502, Virulence, Session-3: Periodontal and peri-implant diseases, biology.organism_classification, Phenotype, Genome, lcsh:Microbiology, Microbiology, lcsh:Infectious and parasitic diseases, Infectious Diseases, Genotype, Dentistry (miscellaneous), lcsh:RC109-216, Abstract, Bacteria |
| الوصف: | Aggregatibacter actinomycetemcomitans is a Gram-negative periodontitis-associated bacterium that expresses a toxin that selectively affects leukocytes. Leukotoxin is encoded by an operon belonging to the core genome of this bacterial species. Variations in the expression of the leukotoxin have been reported, and a specific clonal type (JP2) of this bacterium with enhanced leukotoxin expression has been identified. Experimental studies have shown that leukotoxin, besides to kill leukocytes, also activates a substantial pro-inflammatory response in these cells. Characterization of clinical isolates from individuals with different geographic origin, age and periodontal status linked carriership of highly leukotoxic A. actinomycetemcomitans to disease. These highly virulent bacteria are of serotype b and have several common phenotypic and genetic features. Based on a great genetic diversity, A. actinomycetemcomitans can be distributed into a high number of different genotypes with various virulence capacities. It can be concluded that carriership of highly leukotoxic bacteria is associated with a significantly increased risk for initiation of aggressive forms of periodontitis. |
| اللغة: | English |
| تدمد: | 2000-2297 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7536575796b40994508b5abb1d1d9636 https://doaj.org/article/476a6a4de4384ae5b5c2f935d903c2bb |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7536575796b40994508b5abb1d1d9636 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20002297 |
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