Two cases synchronous atypical parathyroid adenomas and papillary thyroid carcinoma
| العنوان: | Two cases synchronous atypical parathyroid adenomas and papillary thyroid carcinoma |
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| المؤلفون: | Natalia Mokrysheva, A. M. Lapshina, Larisa E. Gurevich, Sergey N. Kuznetsov, I V Kim, Timur Britvin, Ludmila Rozhinskaya, Alexey V. Krivosheev, Iya Voronkova |
| المصدر: | Клиническая и экспериментальная тиреоидология, Vol 13, Iss 4, Pp 40-48 (2018) |
| بيانات النشر: | Endocrinology Research Centre, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, endocrine system diseases, 030209 endocrinology & metabolism, Gastroenterology, papillary thyroid carcinomas, Diseases of the endocrine glands. Clinical endocrinology, Thyroid carcinoma, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, primary hyperparathyroidism, atypical parathyroid adenoma, Thyroid cancer, Parathyroid adenoma, Hyperparathyroidism, Parathyroid neoplasm, business.industry, Medullary thyroid cancer, General Medicine, medicine.disease, RC648-665, Parathyroid carcinoma, 030220 oncology & carcinogenesis, business, Primary hyperparathyroidism |
| الوصف: | Most clinicians are well aware of the coexistence of medullary thyroid cancer and hyperparathyroidism in hereditary and sporadic multiple endocrine neoplasia syndromes. Тhe reported incidence of nonmedullary thyroid carcinoma in patients with primary hyperparathyroidism (pHPT) is only approximately 3%. Papillary thyroid carcinomas (PTC) is a malignant epithelial tumour. PTC represent up to 87% of all thyroid carcinomas. Atypical parathyroid adenoma (APA) are a subset of parathyroid neoplasms that exhibit some of the features of parathyroid carcinoma but lack unequivocal invasive growth. APA represents about 0.5–4% of cases of PHPT. As a group, they may be considered tumors of uncertain malignant potential. The clinical importance, and long-term outcomes as well as appropriate operative management and surveillance are not well defined for APA probably due to the overall low prevalence as well as the lack of a standard definition of APA. We report two cases of a 63-year-old woman and 57-year-old man with a synchronous atypical parathyroid adenoma and papillary thyroid carcinoma. One of this patients had a classic symptoms of pHPT, including severe metabolic bone disease and renal disease, but another didn’t have. The mean preoperative calcium was 3,48 and 4,1 (range 2.12–2.6) mmol/l and a mean parathyroid hormone (PTH) of 1300 and 1533 (range 15–65) pg/ml, respectively. Thyroid ultrasound didn’t show a nodule with features of the thyroid carcinoma in both cases. The thyroid cancer was suspected after intraoperative revision. The patients underwent a total thyroidectomy and surgical excision of the parathyroid adenoma. Surgical pathology showed papillary microcarcinoma in both cases (in the first – unilateral, in the second – bilateral) and APA. Awareness of this condition will enable clinicians to evaluate for possible thyroid pathology in patients with primary hyperparathyroidism. Both of these endocrine conditions could then be managed with a single surgery involving concomitant resection of the thyroid and parathyroid glands. |
| اللغة: | Russian |
| تدمد: | 2310-3787 1995-5472 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752d8385159db943951993d56571e995 https://cet-endojournals.ru/ket/article/viewFile/9497/7149 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....752d8385159db943951993d56571e995 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23103787 19955472 |
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