Dimensionality-dependent crossover in motility of polyvalent burnt-bridges ratchets
| العنوان: | Dimensionality-dependent crossover in motility of polyvalent burnt-bridges ratchets |
|---|---|
| المؤلفون: | Nancy R. Forde, Chapin S. Korosec, Martin J. Zuckermann |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Physics, Quantitative Biology - Subcellular Processes, Statistical Mechanics (cond-mat.stat-mech), Track (disk drive), Crossover, Monte Carlo method, Ratchet, FOS: Physical sciences, 02 engineering and technology, Parameter space, 021001 nanoscience & nanotechnology, Span (engineering), 01 natural sciences, Gillespie algorithm, Biological Physics (physics.bio-ph), FOS: Biological sciences, 0103 physical sciences, Statistical physics, Physics - Biological Physics, 010306 general physics, 0210 nano-technology, Subcellular Processes (q-bio.SC), Condensed Matter - Statistical Mechanics, Curse of dimensionality |
| الوصف: | The burnt-bridges ratchet (BBR) mechanism is a model for biased molecular motion whereby the construct destroys track binding sites as it progresses, and therefore acts as a diffusing forager, seeking new substrate sites. Using Monte Carlo simulations that implement the Gillespie algorithm, we investigate the kinetic characteristics of simple polyvalent BBRs as they move on tracks of increasing width. We find that as the track width is increased the BBRs remain nearly ballistic for considerable track widths proportional to the span (leg length) of the polyvalent walker, before transitioning to near-conventional diffusion on two-dimensional tracks. We find there exists a tradeoff in BBR track association time and superdiffusivity in the BBR design parameter space of span, polyvalency and track width. Furthermore, we develop an analytical model to describe the ensembleaverage motion on the track and find it is in good agreement with our Gillespie simulation results. This work offers insights into design criteria for de novo BBRs and their associated tracks, where experimentalists seek to optimize directionality and track association time. Includes SI, but not supporting movies |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751a5b89fced125a7759a6a49da17a0e http://arxiv.org/abs/1806.08066 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....751a5b89fced125a7759a6a49da17a0e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |