Optimized outcome prediction of oncogenetic mutations in non-early T-cell precursor acute lymphoblastic leukemia
| العنوان: | Optimized outcome prediction of oncogenetic mutations in non-early T-cell precursor acute lymphoblastic leukemia |
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| المؤلفون: | Li-Jun Peng, Si-Si Wang, Shan-Shan Guo, Jiao-Jiao Zhang, Yuan-Fang Liu, Sophie Rousseaux, Saadi Khochbin, Bing Chen, Jin Wang, Jian-Qing Mi |
| المساهمون: | Shanghai Jiao Tong University School of Medicine, Pôle de Recherches Sino-Français en Science du Vivant et Génomique [Shanghai, China] (RSF-SVG), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Khochbin, Saadi |
| المصدر: | Immunobiology Immunobiology, 2022, 227 (3), pp.152205. ⟨10.1016/j.imbio.2022.152205⟩ |
| بيانات النشر: | HAL CCSD, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, China, Precursor Cells, T-Lymphoid, F-Box-WD Repeat-Containing Protein 7, Immunology, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Hematology, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, [SDV.CAN] Life Sciences [q-bio]/Cancer, Mutation, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Immunology and Allergy, Humans |
| الوصف: | International audience; Background: Early biomarkers allowing effective treatment stratification in adult T-cell acute lymphoblastic leukemia (T-ALL) patients remain elusive.Materials and methods: The mutation spectrum of 116T-ALL adult patients enrolled in the Shanghai Institute of Hematology (SIH)-based hospital network or Multicenter Hematology-Oncology Protocols Evaluation System (M-HOPES) in China were studied by using RNA-sequencing or targeted next generation sequencing. A comprehensive survival analysis based on clinical characteristics, immunophenotype and oncogenetic classifier was performed.Results: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) has higher mutation rates of N/K-RAS and lower mutation rates of FBXW7 compared to non-ETP ALL, but the survival probability of ETP-ALL patients is similar to that of non-ETP ALL patients. T-ALLs with a NOTCH1/FBXW7 (N/F) mutation in the absence of RAS or PTEN abnormalities (NFRP class I) show a more favorable outcome compared to T-ALLs with no N/F mutation and/or with the presence of RAS/PTEN alterations (NFRP class II). A survival analysis of TALL , taking into account both the ETP-ALL/non-ETP TALL groups and the NFRP oncogenetic classifier, demonstrates that, within the non-ETP TALL subtype, NFRP class II identifies a group with poor prognosis and significant decreases of both OS (14.8% versus 50.9%, P = 0.019) and EFS (11.4% versus 42.4%, P = 0.001). In contrast, no survival difference is observed within ETP-ALL between the NFRP class I or class II (OS: 37.9% versus 33%, P = 0.876; EFS: 39.8% versus 33.7%, P = 0.969).Conclusion: In summary, the oncogenetic classifier based on the NFRP classes is particularly useful to improve the stratification of non-ETP ALL. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0171-2985 |
| DOI: | 10.1016/j.imbio.2022.152205⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75078d0e3fb155ff0fdbd39a5fb423ba https://hal.science/hal-03759793/file/Peng_et_al.pdf |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....75078d0e3fb155ff0fdbd39a5fb423ba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01712985 |
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| DOI: | 10.1016/j.imbio.2022.152205⟩ |