Amitriptyline eliminates calculi through urinary tract smooth muscle relaxation
| العنوان: | Amitriptyline eliminates calculi through urinary tract smooth muscle relaxation |
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| المؤلفون: | Nestor Schor, Alexandre H. Campos, Eduardo Achar, Rosi Aparecida Nunes Achar, Therezinha B. Paiva |
| المساهمون: | Universidade Federal de São Paulo (UNIFESP), Sao Teodoro Vet Hosp |
| المصدر: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| بيانات النشر: | Elsevier BV, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Male, obstructive acute renal failure, medicine.medical_specialty, Swine, Muscle Relaxation, Urinary system, Urinary Bladder, Urology, amitriptyline, In Vitro Techniques, Ureter, Urethra, relaxation, Internal medicine, medicine, Animals, Humans, Amitriptyline, Rats, Wistar, Urinary Tract, Urinary bladder, business.industry, urolithiasis, Acute kidney injury, Muscle, Smooth, Potassium channel blocker, Acute Kidney Injury, medicine.disease, Rats, medicine.anatomical_structure, Endocrinology, Muscle relaxation, Potassium Channels, Voltage-Gated, Nephrology, Cats, Urinary Calculi, urinary tract smooth muscle, business, voltage-dependent potassium channel, medicine.drug |
| الوصف: | Background. We investigated the effects of amitriptyline in the urinary tract smooth muscle and urolithiasis.Methods. Cats presenting with obstructive acute renal failure (ARF) received amitriptyline, and renal function and survival rates were analyzed. Isometric contractions and membrane potentials of rat, pig, or human isolated urinary tract smooth muscle were recorded in the presence or absence of amitriptyline.Results. Twenty cats with obstructive ARF caused by urethral plugs received amitriptyline. in all cases, plugs were completely eliminated, and renal function returned to normal, with a 100% survival rate in the follow-up. Amitriptyline produced potent relaxations in rat urethral strips, accompanied by significant reductions in urethral ring membrane potential. This effect was prevented by pretreatment of urethral rings with 4-aminopyridine (4-AP), a voltage-dependent potassium channel blocker. Amitriptyline abolished in a reversible manner acetylcholine-, bradykinin-, and KCl-induced contractions in rat isolated bladder, and this effect was also prevented by 4-AP. of interest, spontaneous and KCl-induced contractions of pig and human isolated ureter were also blocked by amitriptyline.Conclusion. Our results indicate that amitriptyline is an effective and potent relaxant of urinary tract smooth muscle and this effect is mediated by opening of voltage dependent-potassium channels. We suggest that amitriptyline administration may help to promote elimination of urinary calculi. Universidade Federal de São Paulo, Escola Paulista Med, Dept Med, Div Nephrol, BR-04023062 São Paulo, Brazil Sao Teodoro Vet Hosp, São Paulo, Brazil Universidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, BR-04023062 São Paulo, Brazil Universidade Federal de São Paulo, Escola Paulista Med, Dept Med, Div Nephrol, BR-04023062 São Paulo, Brazil Universidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, BR-04023062 São Paulo, Brazil Web of Science |
| تدمد: | 0085-2538 |
| DOI: | 10.1046/j.1523-1755.2003.00222.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741f6b04126d197090cc161a2e8f0416 https://doi.org/10.1046/j.1523-1755.2003.00222.x |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....741f6b04126d197090cc161a2e8f0416 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00852538 |
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| DOI: | 10.1046/j.1523-1755.2003.00222.x |