Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer's disease
| العنوان: | Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer's disease |
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| المؤلفون: | Manu Rangachari, Isabelle Paré, Isabelle St-Amour, Prenitha Mercy Ignatius Arokia Doss, Sébastien S. Hébert, Frédéric Calon, Renée Bazin, Cristina R. Bosoi |
| المصدر: | Journal of Neuroinflammation Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Adaptive immune system, Helper T lymphocyte, Lymphocyte, Adaptive Immunity, Neurodegenerative disease, Hematopoietic stem cell, lcsh:RC346-429, Monocytes, Amyloid beta-Protein Precursor, Mice, 0302 clinical medicine, Bone Marrow, Lymphocytes, General Neuroscience, ELISPOT, Cell Polarity, Neurofibrillary Tangles, Lymphocyte egress, Acquired immune system, 3. Good health, medicine.anatomical_structure, Neurology, Cytokines, Th17, Alzheimer’s disease, Immunology, Mice, Transgenic, tau Proteins, 03 medical and health sciences, Cellular and Molecular Neuroscience, Immunity, Alzheimer Disease, medicine, Presenilin-1, Animals, Humans, lcsh:Neurology. Diseases of the nervous system, Inflammation, Amyloid beta-Peptides, business.industry, Monocyte, Research, 030104 developmental biology, Mutation, Bone marrow, business, 030217 neurology & neurosurgery, Spleen, Granulocytes |
| الوصف: | Background Immunologic abnormalities have been described in peripheral blood and central nervous system of patients suffering from Alzheimer’s disease (AD), yet their role in the pathogenesis still remains poorly defined. Aim and methods We used the triple transgenic mouse model (3xTg-AD) to reproduce Aβ (amyloid plaques) and tau (neurofibrillary tangles) neuropathologies. We analyzed important features of the adaptive immune system in serum, primary (bone marrow) as well as secondary (spleen) lymphoid organs of 12-month-old 3xTg-AD mice using flow cytometry and ELISPOT. We further investigated serum cytokines of 9- and 13-month-old 3xTg-AD mice using multiplex ELISA. Results were compared to age-matched non-transgenic controls (NTg). Results In the bone marrow of 12-month-old 3xTg-AD mice, we detected decreased proportions of short-term reconstituting hematopoietic stem cells (0.58-fold, P = 0.0116), while lymphocyte, granulocyte, and monocyte populations remained unchanged. Our results also point to increased activation of both B and T lymphocytes. Indeed, we report elevated levels of plasma cells in bone marrow (1.3-fold, P = 0.0405) along with a 5.4-fold rise in serum IgG concentration (P |
| تدمد: | 1742-2094 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fbde3c844177c599ae2f47fe6eca5d https://pubmed.ncbi.nlm.nih.gov/30611289 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....72fbde3c844177c599ae2f47fe6eca5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17422094 |
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