HoxB genes regulate neuronal delamination in the trunk neural tube by controlling the expression of Lzts1
| العنوان: | HoxB genes regulate neuronal delamination in the trunk neural tube by controlling the expression of Lzts1 |
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| المؤلفون: | Laure Lo Re, Axelle Wilmerding, Andrew J. Saurin, Yacine Graba, Emilie Bonzom, Marie-Claire Delfini, Lucrezia Rinaldi, Nathalie Caruso |
| المساهمون: | Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Division of Hematology, Department of Medicine and the Cancer Center, Harvard Initiative of RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA, King’s College London, Wolfson Centre for Age-Related Diseases, London SE1 1UL, UK |
| المصدر: | Development Development, 2021, ⟨10.1242/dev.195404⟩ |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Leucine zipper, Neurogenesis, [SDV]Life Sciences [q-bio], Biology, 03 medical and health sciences, 0302 clinical medicine, medicine, Hox gene, Molecular Biology, Gene, 030304 developmental biology, 0303 health sciences, Spinal cord development, Neural tube, HOXB8, Embryo, Chicken embryo, Spinal cord, Lzts1, Cell biology, Hox transcription factors, medicine.anatomical_structure, Delamination, 030217 neurology & neurosurgery, Developmental Biology |
| الوصف: | Differential Hox gene expression is central for specification of axial neuronal diversity in the spinal cord. Here, we uncover an additional function of Hox proteins in the developing spinal cord, restricted to B cluster Hox genes. We found that members of the HoxB cluster are expressed in the trunk neural tube of chicken embryo earlier than Hox from the other clusters, with poor antero-posterior axial specificity and with overlapping expression in the intermediate zone (IZ). Gain-of-function experiments of HoxB4, HoxB8 and HoxB9, respectively, representative of anterior, central and posterior HoxB genes, resulted in ectopic progenitor cells in the mantle zone. The search for HoxB8 downstream targets in the early neural tube identified the leucine zipper tumor suppressor 1 gene (Lzts1), the expression of which is also activated by HoxB4 and HoxB9. Gain- and loss-of-function experiments showed that Lzts1, which is expressed endogenously in the IZ, controls neuronal delamination. These data collectively indicate that HoxB genes have a generic function in the developing spinal cord, controlling the expression of Lzts1 and neuronal delamination. |
| اللغة: | English |
| DOI: | 10.1242/dev.195404⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72eb00aa97cdba73bda2bd74a01e9948 https://hal.science/hal-03366252/document |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....72eb00aa97cdba73bda2bd74a01e9948 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.1242/dev.195404⟩ |
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