Response to BNT162b2 Sars-Cov-2 Vaccine in Recipients of Allogeneic Hematopoietic Stem Cell Transplant
| العنوان: | Response to BNT162b2 Sars-Cov-2 Vaccine in Recipients of Allogeneic Hematopoietic Stem Cell Transplant |
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| المؤلفون: | Stella Santarone, Marta Lisa Battista, Alessandro Fiorentini, Irene Federici, Luca Butini, Massimo Offidani, Sonia Morè, Giorgia Mancini, Doriana Vaddinelli, Sadia Falcioni, Annalisa Natale, Fabrizio Pane, Angelo Michele Carella, Giorgia Battipaglia, Nadia Viola, Shahram Kordasti, Martina Chiarucci, Andrea Costantini, Selene Guerzoni, Francesca Patriarca, Piero Galieni, Fabrizia Colasante, Benedetta Corvaro, Giuseppe Visani, Ilaria Scortechini, Stefano Menzo, Francesco Saraceni, Sara Caucci, Attilio Olivieri, Bruna Puglisi, Maria Vittoria Dubbini |
| المصدر: | Blood |
| بيانات النشر: | American Society of Hematology. Published by Elsevier Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Medicine, Cell Biology, Hematology, Allogeneic hematopoietic stem cell transplant, business, Biochemistry, 722.Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution |
| الوصف: | Recipients of allogeneic hematopoietic stem cell transplant (HSCT) have been excluded from clinical trials of SARS-CoV-2 messenger RNA (mRNA) vaccines; however, since these patients are at higher risk of severe complications following infection, they have been given high priority in vaccination campaigns worldwide. In this prospective observational study, we evaluated the immunogenicity of two BNT162b2 (Pfizer-BioNTech) vaccine doses in allogeneic HSCT recipients compared to healthy controls. IgG antibodies to the receptor-binding domain (RBD) of the S1 subunit of the spike protein of SARS-CoV-2 were analyzed by SARS-CoV-2 IgG II Quant (Abbott, Ireland). The cutoff value of the test used in this study is 7.1 BAU/mL (Binding Antibody Unit/mL) and the results greater than 7.1 indicate that seroconversion has occurred, as recommended by the manufacturer. Peripheral blood samples were collected for immunological analysis at three timepoints: pre-vaccine baseline (w0, before the first BNT162b2 dose), week 3 (w3, before the second vaccine dose) and week 5 (w5, 2 weeks following the second dose). Patients older than 18 years who received BNT162b2 vaccine following an HSCT at seven Italian centers were included in the study. Enrolled patients received two successive doses (at 3-week interval) at a median of 15 months (range 2-141) after HSCT. Twenty-nine age-matched health care workers who were vaccinated with BNT162b2 were recruited as the control group. Among the 34 patients evaluable for serological response, three patients were excluded from the analysis as the baseline serology demonstrated previous natural SARS-CoV-2 infection. On w3, after the first vaccine dose 7/31 (23%) patients developed anti-S IgG antibodies as compared to 28/29 (97%) controls (p12 months, p200/mm3, p=0.01), and CD4+CD45RA+ T naive cell count (>100/ mm3, p Figure 1 Figure 1. Disclosures Kordasti: Alexion: Honoraria; Celgene: Research Funding; Beckman Coulter: Honoraria; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. Pane: AbbVie; Amgen; Novartis: Other: Travel, accommodation, expenses; AbbVie; Amgen; Novartis, GSK, Incyte: Speakers Bureau; Novartis Pharma SAS;: Research Funding; AbbVie; Amgen; Novartis, GSK , Incyte: Consultancy. |
| اللغة: | English |
| تدمد: | 1528-0020 0006-4971 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d9cdf67de08d6e579ad66a0f9e5052 http://europepmc.org/articles/PMC8701610 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....72d9cdf67de08d6e579ad66a0f9e5052 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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